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MABE159 Anti-Fox1 Antibody, clone D8F8

Anti-Fox1 Antibody, clone D8F8 is a Mouse Monoclonal Antibody for detection of Fox1 also known as hexaribonucleotide binding protein 1, Ataxin-2-binding protein 1 & has been validated in WB.

Anti-Fox1 Antibody, clone D8F8 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: RNA Metabolism & Binding Proteins Gene Symbol: FOX1, A2BP1, A2BP UniProt Number: Q9JJ43
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MABE159
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABE159
      DescriptionAnti-Fox1 Antibody, clone D8F8
      Alternate Names
      • hexaribonucleotide binding protein 1
      • Ataxin-2-binding protein 1
      • ataxin 2-binding protein 1
      • Hexaribonucleotide-binding protein 1
      • fox-1 homolog A
      Background InformationFox1, also commonly referred to as Ataxin-2-binding protein 1, is an RNA binding protein involved in the regulation of tissue-specific alternative splicing. This protein contains a highly conserved RRM (RNA recognition motif) and associates with 5'-UGCAUGU-3' elements. This protein has been demonstrated to regulate alternative splicing of tissue specific exons and differentially spliced exons during erythropoiesis. Its alternative name, Ataxin-2-binding protein, is a result of its association with the C terminus of ataxin 2 which may contribute to the pathology of the neurogenerative disease spinocerebellar ataxia type 2 (SCA2).
      References
      Product Information
      FormatPurified
      Control
      • Mouse heart tissue lysate
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Fox1 Antibody, clone D8F8 is a Mouse Monoclonal Antibody for detection of Fox1 also known as hexaribonucleotide binding protein 1, Ataxin-2-binding protein 1 & has been validated in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenRecombinant protein corresponding to mouse Fox1.
      CloneD8F8
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FOX1
      • A2BP1
      • A2BP
      Purification MethodProtein G
      UniProt Number
      UniProt SummaryFUNCTION: RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.

      SUBUNIT STRUCTURE: Binds to the C-terminal of ATXN2.

      SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Predominantly nuclear.

      TISSUE SPECIFICTY: Detected in brain (at protein level). Detected in heart, brain, neurons, skeletal muscle and embryo.

      SEQUENCE SIMILARITIES: Contains 1 RRM (RNA recognition motif) domain.
      Molecular Weight~55 kDa observed. Uncharacterized bands potentially due to alternative splicing have been observed at ~33 and 37 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in mouse heart tissue lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected Fox1 on 10 µg of mouse heart tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABE159 04053252749681

      Documentation

      Anti-Fox1 Antibody, clone D8F8 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Fox1 Antibody, clone D8F8 Certificates of Analysis

      TitleLot Number
      Anti-Fox1, clone D8F8 - 2432507 2432507
      Anti-Fox1, clone D8F8 - 2327491 2327491
      Anti-Fox1, clone D8F8 - 3260209 3260209
      Anti-Fox1, clone D8F8 - 3365623 3365623
      Anti-Fox1, clone D8F8 - NRG1845791 NRG1845791
      Anti-Fox1, clone D8F8 -2515706 2515706
      Anti-Fox1, clone D8F8 -2562370 2562370
      Anti-Fox1, clone D8F8 -2584875 2584875
      Anti-Fox1, clone D8F8 -2686152 2686152
      Anti-Fox1, clone D8F8 Monoclonal Antibody 2972029

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies