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MABN313 Anti-DEXRAS1 Antibody, clone 4B11.1

Anti-DEXRAS1 Antibody, clone 4B11.1 is an antibody against DEXRAS1 for use in Western Blotting, Immunohistochemistry (Paraffin).

Anti-DEXRAS1 Antibody, clone 4B11.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: G-proteins Gene Symbol: RASD1, AGS1, DEXRAS1 UniProt Number: Q9Y272
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MABN313
100 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN313
      DescriptionAnti-DEXRAS1 Antibody, clone 4B11.1
      Alternate Names
      • Dexamethasone-induced Ras-related protein 1
      • Activator of G-protein signaling 1
      Background InformationDexamethasone-induced Ras-related protein 1 (UniProt Q9Y272; also known as Activator of G-protein signaling 1) is encoded by the RASD1 (also known as AGS1, DEXRAS1) gene (Gene ID 51655) in human. Rasd1/Dexras belongs to the monomeric Ras superfamily of GTPases that are commonly referred to as small G-proteins. Rasd1/Dexras1 is a small G protein that functions as an important signal transducer in regulating circadian rhythms, GH secretion, and cell growth. Rasd1/Dexras is rapidly up-regulated by the synthetic glucocorticoid dexamethasone as a result of GR-STAT5b complex-mediated transcription. Rasd1/Dexras1 interacts with neuronal nitric oxide synthase (nNOS or bNOS) via the scaffolding protein CAPON, with nitric oxide serving as a guanine nucleotide exchange factor for Rasd1/Dexras1. Rasd1/Dexras1 is induced by glucocorticoids during adipogenic differentiation. Exogenous Rasd1/Dexras1 expression rescues impaired adipogenesis of Dexras1-deficient mouse embryonic fibroblasts (MEFs). Dexras1 knockout mice display impaired adiposity and are resistant to diet-induced weight gain. Human, moue, and rat Rasd1/Dexras1 protein is initially produced with a 3-amino acid propeptide sequence at the C-terminal end, which was posttranslationally removed to yield the mature protein.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-DEXRAS1 Antibody, clone 4B11.1 is an antibody against DEXRAS1 for use in Western Blotting, Immunohistochemistry (Paraffin).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected DEXRAS1 in 10 µg of mouse brain tissue lysate.
      Immunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected DEXRAS1 in rat testis, mouse cerebellum, and human kidney tissue sections.
      Biological Information
      ImmunogenGST-tagged recombinant human DEXRAS1 internal fragment.
      EpitopeInternal.
      Clone4B11.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 4B11.1 detects an epitope conserved among human, mouse, and rat RASD1 protein, but missing in human RASD1 spliced isoform 2 reported by UniProt (Q9Y272).
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • RASD1
      • AGS1
      • DEXRAS1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~32 kDa oberved. 31.64/31.68/31.71 kDa (human/mouse/rat pro-form) and 31.34/31.38/31.41 kDa (human/mouse/rat mature form) calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat brain tissue lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected DEXRAS1 in 10 µg of rat brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN313 04055977350333

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies