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MABF2051-100UG Anti-Chikungunya virus Antibody, clone 6A11

Anti-Chikungunya virus, clone 6A11, Cat. No. MABF2051 is a mouse monoclonal antibody that detects E1 protein of Chikungunya virus (CHIKV) and has been tested for use in Immunocytochemistry and Western Blotting.

Anti-Chikungunya virus Antibody, clone 6A11 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Gene Symbol: E1
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MABF2051-100UG
100 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      VirusICC, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF2051-100UG
      DescriptionAnti-Chikungunya virus Antibody, clone 6A11
      Alternate Names
      • CHIKV
      • E1 Protein
      Background InformationChikungunya virus (CHIKV) that causes distinctive polyarthritis or polyarthralgia with clinical features such as fever, maculopapular rash, and myalgia is transmitted by Aedes spp of mosquitoes. Immune compromised individuals may face serious complications, including encephalitis and mortality. CHIKV genome contains a single-stranded positive-sense RNA that encodes four non-structural proteins known as nsP1, nsP2, nsP3, and nsP4 and also five structural proteins that include a capsid protein, three envelope glycoproteins known as (E1, E2, and E3, and a small molecule known as 6K. The mature alphavirus particles express E1 and E2 heterodimers that form 80 trimeric spikes on the surface of the virion. The ectodomain E1 protein consists of three domains known as D1, DII, and DIII. The DIII domain is an immunoglobulin-like domain connected to D1 and DII by a flexible linker. Both E1 and E2 proteins are responsible for virus entry into host cells. The E2 glycoprotein interacts with a cellular receptor, resulting in the virus internalization and the E1 glycoprotein mediates virus fusion to host cell under low pH conditions. Following the fusion of the viral envelope with the endosomal membrane, the viral genomic RNA is released into the cytoplasm and starts replicating. (Ref.: Marsinoul, P., et al. (2014). Virology 464-465; 111-117; Lam, S., et al. (2015). mAbs 7(6), 1178-1194).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Chikungunya virus, clone 6A11, Cat. No. MABF2051 is a mouse monoclonal antibody that detects E1 protein of Chikungunya virus (CHIKV) and has been tested for use in Immunocytochemistry and Western Blotting.
      Key Applications
      • Immunocytochemistry
      • Western Blotting
      Application NotesWestern Blotting Analysis: A 1:100 dilution from a representative lot detected Chikungunya virus in BHK cells infected with CHIKV (Courtesy of an outside independent laboratory).

      Immunocytochemistry Analysis: A representative lot detected Chikungunya virus in BHK cells infected with CHIKV (Courtesy of an outside independent laboratory).
      Biological Information
      ImmunogenCH122508 strain of Chikungunya virus.
      Clone6A11
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 6A11 specifically detects Chikungunya virus in infected cells.
      IsotypeIgG2bκ
      Species Reactivity
      • Virus
      Species Reactivity NoteVirus.
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • E1
      Purification MethodProtein G purified
      Molecular Weight~9.17 kDa calculated for E1 protein. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceIsotype testing: Identity Confirmation by Isotyping Test.

      Isotyping Analysis: The identity of this monoclonal antibody is confirmed by isotyping test to be mouse IgG2b .
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABF2051-100UG 04054839431913