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ABC343 Anti-Caspase-10 Antibody

Detect Caspase 10 using this rabbit polyclonal antibody, Anti-Caspase-10 Antibody validated for use in western blotting.

Anti-Caspase-10 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: CASP10 UniProt Number: Q92851
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ABC343
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC343
      DescriptionAnti-Caspase-10 Antibody
      Alternate Names
      • Casp-10
      • Caspase-10
      Background InformationCaspase-10 is a member of the peptidase C14A family and is involved in the activation cascade of caspases responsible for apoptosis execution. Caspase-10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits both TNFR1 and CD95 to form complexes with these receptors. Caspase-10 is expressed in many tissues and cell lines with the lowest expression found in brain, kidney, prostate, testis, and colon. Mutations in Caspase-10 have been associated with autoimmune lymphoproliferative syndrome type 2A and gastric cancer.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HeLa, Jurkat, A431, and K562 whole cell lysates
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Caspase 10 using this rabbit polyclonal antibody, Anti-Caspase-10 Antibody validated for use in western blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the C-terminus of human Caspase-10.
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the C-terminus of Caspase-10.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • CASP10
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~59 kDa observed. Uniprot describes 6 isoforms ranging from ~31 kDa to ~59 kDa. Uncharacterized bands may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa, Jurkat, A431, and K562 whole cell lysates.

      Western Blotting Analysis: 1 µg/mL of this antibody detected Caspase-10 in 15 µg of HeLa, Jurkat, A431, and K562 whole cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABC343 04053252862731