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MABN282 Anti-CNGB1 Antibody, clone 5A5.1

Detect CNGB1 using this Anti-CNGB1 Antibody, clone 5A5.1 validated for use in western blotting.

Anti-CNGB1 Antibody, clone 5A5.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: CNGB1, CNCG2, CNCG3L, CNCG4, RCNC2 UniProt Number: Q14028
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MABN282
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN282
      DescriptionAnti-CNGB1 Antibody, clone 5A5.1
      Alternate Names
      • Cyclic nucleotide-gated cation channel beta-1
      • Cyclic nucleotide-gated cation channel 4
      • CNG channel 4
      • CNG-4
      • CNG4
      • Cyclic nucleotide-gated cation channel gamma
      • Cyclic nucleotide-gated cation channel modulatory subunit
      • Cyclic nucleotide-gated channel beta-1
      • CNG channel beta-1
      • Glutamic acid-rich protein
      • GARP
      Background InformationCNGB1, also known as Cyclic nucleotide-gated cation channel beta-1, Cyclic nucleotide-gated cation channel 4 (CNG4), Cyclic nucleotide-gated cation channel gamma, Cyclic nucleotide-gated cation channel modulatory subunit, Cyclic nucleotide-gated channel beta-1, or Glutamic acid-rich protein (GARP), and encoded by the gene CNGB1/CNCG2/CNCG3L/CNCG4/RCNC2, is a subunit of cyclic nucleotide-gated (CNG) channels which are nonselective cation channels expressed in retinal and olfactory neurons. The CNG channels play important roles in both visual and olfactory signal transduction. When associated with CNGA1, CNGB1 is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. CNGB1 is localized in the plasma membranes of expressing cells and mediates the ion transport of the channel. Mutations in CNGB1 are associated with the genetic disease retinitis pigmentosa 45 that is a progressive vision disease associated with the loss of rod and cone photoreceptors.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect CNGB1 using this Anti-CNGB1 Antibody, clone 5A5.1 validated for use in western blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human CNGB1.
      Clone5A5.1
      Concentration1 mg/mL
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CNGB1
      • CNCG2
      • CNCG3L
      • CNCG4
      • RCNC2
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~140 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Y79 cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected CNGB1 in 10 µg of Y79 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN282 04053252973925