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07-590-25UG Anti-Ago 2 (rabbit polyclonal IgG)

Anti-Ago 2 Antibody is a Rabbit Polyclonal Antibody for detection of Ago 2 also known as argonaute 2 & has been tested in WB.

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07-590-25UG
25 μg  
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      Description
      Catalogue Number07-590-25UG
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Ago 2 (rabbit polyclonal IgG)
      Background InformationThis gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing.

      Provides endonuclease activity to RNA-induced silencing complexes (RISC). Cleaves siRNA/mRNA heteroduplexes bound to RISC. Essential for embryonic development as well as RNA-mediated gene silencing (RNAi).
      References
      Product Information
      FormatPurified
      Control
      • HeLa cell lysate, HL-60 cell lysate
      PresentationProtein A Purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide as a preservative.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Ago 2 Antibody is a Rabbit Polyclonal Antibody for detection of Ago 2 also known as argonaute 2 & has been tested in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST fusion protein corresponding to residues 7-48 of human argonaute 2 (Ago2).
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityRecognizes Ago 2, also known as eukaryotic translation initiation factor 2C, 2 (EIF2C 2), MGC3183 and Q10.
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing.
      Gene Symbol
      • EIF2C2
      • AGO2
      • Q10
      • PPD
      • MGC3183
      • Argonaute-2
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9UKV8 # Provides endonuclease activity to RNA-induced silencing complexes (RISC). Cleaves siRNA/mRNA heteroduplexes bound to RISC. Essential for embryonic development as well as RNA-mediated gene silencing (RNAi) (By similarity).
      SIZE: 851 amino acids; 96799 Da
      SUBUNIT: Interacts with DICER1 through its Piwi domain.
      SUBCELLULAR LOCATION: Cytoplasm, P-body. Note=Cytoplasmic bodies.
      DOMAIN:SwissProt: Q9UKV8 Piwi domain is thought to provide RNA cleavage activity with a mechanism similar to RNase H (By similarity).
      SIMILARITY: Belongs to the argonaute family. & Contains 1 PAZ domain. & Contains 1 Piwi domain.
      Molecular Weight100 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot in RIPA and cytosolic lysates from HeLa cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 1 year at 2-8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      07-590-25UG 04054839342516

      Documentation

      Anti-Ago 2 (rabbit polyclonal IgG) Certificates of Analysis

      TitleLot Number
      Anti-Ago 2 - 3433057 3433057

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