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AB2959 Anti-ADAM 9 Antibody, disintegrin domain

Detect ADAM 9 using this Anti-ADAM 9 Antibody, disintegrin domain validated for use in WB.

Anti-ADAM 9 Antibody, disintegrin domain MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: MMPs & TIMPs Gene Symbol: ADAM9, Mltng, MDC9, ADAM12, MCMP, MCMP-PEN, MLTNG, Meltrin-gamma UniProt Number: Q13443
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AB2959
100 µg  
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      Overview

      Replacement Information

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, Pm, ChpWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB2959
      ReplacesAB19025
      DescriptionAnti-ADAM 9 Antibody, disintegrin domain
      Alternate Names
      • ADAM metallopeptidase domain 9 (meltrin gamma)
      • a disintegrin and metalloproteinase domain 9 (meltrin gamma)
      • Cellular disintegrin-related protein
      • Myeloma cell metalloproteinase
      • Metalloprotease/disintegrin/cysteine-rich protein 9
      Background InformationA disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) belongs to a family of transmembrane, membrane-anchored, disintegrin-containing proteins that are involved in several biological functions such as protein ectodomain shedding, cell fusion, and cell adhesion. ADAMs contain several characteristic domains, two of which, the protease and disintegrin domains, are noted for their homology to snake venom metalloprotease. The exact function of ADAM 9 is yet unknown, however it is widely distributed, is found within keratinocytes, and is ideally placed on the cell membrane, which some studies have suggested supports a role in cell migration and motility. Alternative splicing results in two isoforms; isoform 1 is found within the cell membrane and is considered a single-pass type 1 membrane protein, while isoform 2 is secreted. Mutations in ADAM 9 expression are causal to cone-rod dystrophy type 9 or CORD9 which is characterized by visible retinal pigment deposits and loss of cone photoreceptors leading and rod degeneration, ultimately resulting in severe loss of vision.
      References
      Product Information
      FormatPurified
      Control
      • Human chondrocyte cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect ADAM 9 using this Anti-ADAM 9 Antibody, disintegrin domain validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the disintegrin domain of human ADAM 9.
      Epitopedisintegrin domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Primate
      • Chimpanzee
      Species Reactivity NoteDemonstrated to react with human. Predicted to react with primate and chimpanzee based on 100% sequence homology.
      Mouse and rat (90% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Two alternative splice variants have been identified, encoding distinct isoforms. [provided by RefSeq].
      Gene Symbol
      • ADAM9
      • Mltng
      • MDC9
      • ADAM12
      • MCMP
      • MCMP-PEN
      • MLTNG
      • Meltrin-gamma
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays alpha-secretase activity for APP.

      COFACTOR: Binds 1 zinc ion per subunit (Probable).

      SIZE: 819 amino acids; 90556 Da

      SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.

      TISSUE SPECIFICITY: Widely expressed. Expressed in chondrocytes. Highest expression of isoform 2 found in liver and heart.

      SIMILARITY: Contains 1 disintegrin domain. & Contains 1 EGF-like domain. & Contains 1 peptidase M12B domain.
      Molecular Weight~ 90 kDa observed. 2 isoforms are produced by alternative splicing: Isoform 1 at 91 kDa and Isoform 2 at 72 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human chondrocyte cell lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected ADAM 9 in 10 µg of human chondrocyte cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB2959 04053252479731