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178251 α₁-Antitrypsin, Human Plasma - CAS 9041-92-3 - Calbiochem

α₁-Antitrypsin, CAS 9041-92-3, is a protease inhibitor of the serpin superfamily. Inhibits elastase, cathepsin G, and proteinase 3.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α₁-AT, α₁-Proteinase Inhibitor, 3.5S α₁-Glycoprotein

Primary Target: serine proteases
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178251
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Overview

Replacement Information

Key Spec Table

CAS #
9041-92-3

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178251-1MG
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      178251-5MG
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          Description
          OverviewA single polypeptide chain of 394 amino acids and three carbohydrate side chains linked to asparagine residues present at about 290 mg/100 ml in acute phase plasma. Serine protease inhibitor that also acts as a major physiological regulator of elastase. Inhibitor of neutrophil elastase, cathepsin G, and proteinase 3.
          Catalogue Number178251
          Brand Family Calbiochem®
          Synonymsα₁-AT, α₁-Proteinase Inhibitor, 3.5S α₁-Glycoprotein
          References
          ReferencesCoakley, R.J., et al. 2001. Am. J. Med. Sci. 321, 33.
          Travis, J., and Salvesen, G.S. 1983. Annu. Rev. Biochem. 52, 655.
          Product Information
          CAS number9041-92-3
          Activity≥75% inhibition with active-site titrated porcine trypsin using benzoyl-Arg-p-nitroanilide (Bz-Arg-pNA) as the substrate.
          ATP CompetitiveN
          FormSolid
          FormulationLyophilized from 300 mM NaCl, 30 mM sodium phosphate buffer, pH 6.5.
          ReversibleN
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetserine proteases
          Purity≥95% by SDS-PAGE
          SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          178251-1MG 07790788059835
          178251-5MG 04055977223132

          Documentation

          α₁-Antitrypsin, Human Plasma - CAS 9041-92-3 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          α₁-Antitrypsin, Human Plasma - CAS 9041-92-3 - Calbiochem Certificates of Analysis

          TitleLot Number
          178251

          References

          Reference overview
          Coakley, R.J., et al. 2001. Am. J. Med. Sci. 321, 33.
          Travis, J., and Salvesen, G.S. 1983. Annu. Rev. Biochem. 52, 655.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-April-2008 RFH
          Synonymsα₁-AT, α₁-Proteinase Inhibitor, 3.5S α₁-Glycoprotein
          DescriptionA single polypeptide chain of 394 amino acids and three carbohydrate side chains linked to asparagine residues. Present at about 290 mg/100 ml in acute phase plasma. Serine protease inhibitor that also acts as a major physiological regulator of elastase.
          FormSolid
          FormulationLyophilized from 300 mM NaCl, 30 mM sodium phosphate buffer, pH 6.5.
          SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          CAS number9041-92-3
          Purity≥95% by SDS-PAGE
          Activity≥75% inhibition with active-site titrated porcine trypsin using benzoyl-Arg-p-nitroanilide (Bz-Arg-pNA) as the substrate.
          SolubilityH₂O. Please refer to vial label for lot-specific volume prior to lyophilization.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
          Toxicity Standard Handling
          Merck USA index14, 719
          ReferencesCoakley, R.J., et al. 2001. Am. J. Med. Sci. 321, 33.
          Travis, J., and Salvesen, G.S. 1983. Annu. Rev. Biochem. 52, 655.