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203390 (±)-Blebbistatin - CAS 674289-55-5 - Calbiochem

(±)-Blebbistatin, CAS 674289-55-5, is a cell-permeable, selective, and reversible inhibitor of nonmuscle myosin II. Blocks cell blebbing and disrupts cell migration & cytoKinesis in vertebrate cel

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Primary Target: ATPase
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203390
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Overview

Key Spec Table

CAS #Empirical Formula
674289-55-5C₁₈H₁₆N₂O₂

Pricing & Availability

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203390-5MG
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      Description
      OverviewA cell-permeable compound that acts as a selective, potent, and reversible inhibitor of nonmuscle myosin II. Inhibits the ATPase and gliding motility of human platelets (≤ 100 µM) without affecting myosin light chain kinase (MLCK) activity. Has been shown to block cell blebbing and to rapidly disrupt directed cell migration and cytokinesis in vertebrate cells. Does not disrupt mitosis or affect contractile ring assembly. A 50 mM (5 mg/342 µl) solution of (±)-Blebbistatin (Cat. No. 203389) in 90% DMSO is also available.
      Catalogue Number203390
      Brand Family Calbiochem®
      References
      ReferencesShu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
      Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
      Straight, A.F., et al. 2003. Science 299, 1743.
      Cheung, A., et al. 2001. Mol. Biol. Cell Suppl. 12, 271a.
      Product Information
      CAS number674289-55-5
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₈H₁₆N₂O₂
      Chemical formulaC₁₈H₁₆N₂O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetATPase
      Primary Target IC<sub>50</sub><100 µM inhibiting the ATPase and gliding motility of human platelets
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in 90% DMSO, aliquot and freeze (-20°C). Stock solutions in 90% DMSO are stable for up to 1 month at -20°C. Stock solutions in 100% DMSO are unstable; reconstitute just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      203390-5MG 04055977221268