Millipore Sigma Vibrant Logo

23-049 p38/JTV-1 Protein, 10 µg

Full length, recombinant human p38/JTV-1. N-terminal cMyc, GST-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays.

p38/JTV-1 Protein, 10 µg: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Key Applications: Enzyme Assays
View Products on Sigmaaldrich.com
23-049
10 µg  
Preis wird abgerufen...
Preis nicht abrufbar
Die Mindestmenge muss ein Vielfaches sein von
Maximum Quantity is
Bei Bestätigung Weitere Informationen
Sie haben () gespart
 
—
Bitte erfragen
—
Eingeschränkte Verfügbarkeit Eingeschränkte Verfügbarkeit
Lieferbar 
Produkt wurde eingestellt
Begrenzter Lagerbestand
Bestätigung der Verfügbarkeit erforderlich
    Restmenge: Angebot folgt
      Restmenge: Angebot folgt
      Bitte erfragen
      Kontakt zum Kundenservice
      Contact Customer Service

       

      Kontakt zum Kundenservice

      Übersicht

      Replacement Information

      Key Spec Table

      Key ApplicationsSpeciesCascade Component
      Enzyme AssaysHuman Substrate
      Description
      Catalogue Number23-049
      Brand Family Upstate
      Trade Name
      • Upstate
      Descriptionp38/JTV-1 Protein, 10 µg
      Alternate Names
      • Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
      • AIMP2
      • Multisynthase complex auxiliary component p38
      Background Informationp38/JTV-1 is a scaffold required for the assembly and stability of the multi-tRNA synthetase complex, an essential enzyme that ligates specific amino acids to tRNAs before protein synthesis. It plays a pivotal role in the control of cell proliferation and has been shown to interact with FUSE binding protein, stimulating its ubquitination and degradation and leading to the down-regulation of the transcription factor c-Myc which is required for differentiation of functional alveolar type II cells. Genetic disruption of p38/JTV-1 in mice has been observed to cause neonatal lethality.

      p38/JTV-1 is ubiquitinated by the E3 ligase Parkin, leading to its proteosomal degradation. It has been shown to accumulate in Parkin-deficient mice and in the brain tissue of patients with hereditary Parkinson’s, suggesting that it may play a role in the pathogenicity of this disease.
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationFull length, recombinant human p38/JTV-1. N-terminal cMyc, GST-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays.
      Key Applications
      • Enzyme Assays
      Biological Information
      Cascade ComponentSubstrate
      Entrez Gene Number
      Purification MethodPurified using immobilized metal affinity chromatography.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      23-049 04053252649998

      Verwandte Produkte & Anwendungen

      Alternative Packsize

      Bestellnummer Beschreibung  
      23-049M p38/JTV-1 Protein, 250 µg Preis & Verfügbarkeit

      Produktfamilien

      Ubiquitin Proteasome System: Enzymes and Substrates

      Millipore has removed the complexity of Ubiquitination by providing functionally validated enzymes and substrates, making the pathway readily accessible for research and drug discovery.
      Weitere Informationen >>

      Kategorien

      Life Science Research > Drug Discovery and Development > Ubiquitin and Proteasome Screening > Ubiquitination Substrates
      Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Ubiquitination Substrates