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681668 Wnt Synergist, QS11 - CAS 944328-88-5 - Calbiochem

Übersicht

Key Spec Table

CAS #Empirical Formula
944328-88-5C₃₆H₃₃N₅O₂

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681668-5MG
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      Kst.-Ampulle 5 mg
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      Description
      OverviewA cell-permeable purine compound that binds ARFGAPs (Kd = 364 and 620 nM for AMAP1 and ARFGAP1, respectively) and acts as a broad specificity ARFGAPs inhibitor (GTPase activating proteins of ADP-ribosylation factor). Shown to synergize with Wnt-3a and specifically activate the canonical Wnt/β-catenin signaling pathway both in vitro (2-, 40-, and 200-fold increase of basal transcription activity by QS11, Wnt-3a, and QS11/Wnt-3a, respectively, in a Super(8X)TOPFlash reporter assay using HEK293 cells) and in vivo (in the induction of Xenopus embryonic axis duplication). Also reported to block the migration of AMAP1-overexpressing MDA-MB-231 cells (86% inhibition at 2.5 µM).
      Catalogue Number681668
      Brand Family Calbiochem®
      SynonymsQS11, Wnt Pathway Activator II
      References
      ReferencesZhang, Q., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7444.
      Product Information
      CAS number944328-88-5
      FormPale amber solid
      Hill FormulaC₃₆H₃₃N₅O₂
      Chemical formulaC₃₆H₃₃N₅O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥95% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Bestellnummer GTIN
      681668-5MG 04055977260267