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579052 TAPI-2 - CAS 187034-31-7 - Calbiochem

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Key Spec Table

CAS #Empirical Formula
187034-31-7C₁₉H₃₇N₅O₅

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579052-1MG
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      Kst.-Ampulle 1 mg
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      Description
      OverviewA hydroxamate-based inhibitor of MMPs and TACE. Inhibits the activation-induced shedding of L-selectin from neutrophils, eosinophils, and lymphocytes, as well as phenylarsine oxide (PAO)-induced shedding in neutrophils. Also acts as a weak inhibitor of angiotensin converting enzyme (IC50 = 18 µM). Also available as a 10 mM solution in H2O (Cat. No. 509612).
      Catalogue Number579052
      Brand Family Calbiochem®
      SynonymsN-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-t-butyl-alanyl-L-alanine, 2-aminoethyl Amide, TNF-α Protease Inhibitor-2
      References
      ReferencesBennett, T.A., et al. 2000. J. Immunol. 164, 4120.
      Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther. 12, 1139.
      Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
      Parvathy, S., et al. 1997. Biochem. J. 327, 37.
      Arribas, J., et al. 1996. J. Biol. Chem. 271, 11376.
      Product Information
      CAS number187034-31-7
      ATP CompetitiveN
      DeclarationManufactured exclusively by Peptides International, Louisville, Kentucky, USA.
      FormWhite solid
      Hill FormulaC₁₉H₃₇N₅O₅
      Chemical formulaC₁₉H₃₇N₅O₅
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetMMPs
      Primary Target IC<sub>50</sub>18 µM against angiotensin converting enzyme
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Bestellnummer GTIN
      579052-1MG 04055977265378