579052 Sigma-AldrichTAPI-2 - CAS 187034-31-7 - Calbiochem
TAPI-2, CAS 187034-31-7, is a hydroxamate-based inhibitor of MMPs and TACE. Inhibits the activation-induced shedding of L-selectin from neutrophils, eosinophils, and lymphocytes.
More>> TAPI-2, CAS 187034-31-7, is a hydroxamate-based inhibitor of MMPs and TACE. Inhibits the activation-induced shedding of L-selectin from neutrophils, eosinophils, and lymphocytes. Less<<TAPI-2 - CAS 187034-31-7 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-t-butyl-alanyl-L-alanine, 2-aminoethyl Amide, TNF-α Protease Inhibitor-2
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Übersicht
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 187034-31-7 | C₁₉H₃₇N₅O₅ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 579052-1MG |
|
Kst.-Ampulle | 1 mg |
|
— |
| Description | |
|---|---|
| Overview | A hydroxamate-based inhibitor of MMPs and TACE. Inhibits the activation-induced shedding of L-selectin from neutrophils, eosinophils, and lymphocytes, as well as phenylarsine oxide (PAO)-induced shedding in neutrophils. Also acts as a weak inhibitor of angiotensin converting enzyme (IC50 = 18 µM). Also available as a 10 mM solution in H2O (Cat. No. 509612). |
| Catalogue Number | 579052 |
| Brand Family | Calbiochem® |
| Synonyms | N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-t-butyl-alanyl-L-alanine, 2-aminoethyl Amide, TNF-α Protease Inhibitor-2 |
| Product Information | |
|---|---|
| CAS number | 187034-31-7 |
| ATP Competitive | N |
| Declaration | Manufactured exclusively by Peptides International, Louisville, Kentucky, USA. |
| Form | White solid |
| Hill Formula | C₁₉H₃₇N₅O₅ |
| Chemical formula | C₁₉H₃₇N₅O₅ |
| Hygroscopic | Hygroscopic |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | MMPs |
| Primary Target IC<sub>50</sub> | 18 µM against angiotensin converting enzyme |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | N |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Bestellnummer | GTIN |
| 579052-1MG | 04055977265378 |