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616407 TACE Substrate IV, Fluorogenic - Calbiochem

TACE Substrate IV, Fluorogenic - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: TNF-α Convertase Enzyme Substrate IV, Fluorogenic, Abz-LAQAVRSSSR-Dpa, ADAM-17 Substrate IV, Fluorogenic

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616407
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616407-1MG
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      Description
      OverviewAn internally-quenched fluorogenic decapeptide substrate that is useful for continuous monitoring of TACE activity and high-throughput screening of TACE inhibitors (kcat = 21.6 s-1 and substrate concentration at half the Vmax, S0.5 = 342 µM). The substrate is cleaved at Ala-Val amide bond. Acts as a poor substrate for MMP-1, MMP-9, and MMP-13. Displays better solubility in aqueous buffers.
      Catalogue Number616407
      Brand Family Calbiochem®
      SynonymsTNF-α Convertase Enzyme Substrate IV, Fluorogenic, Abz-LAQAVRSSSR-Dpa, ADAM-17 Substrate IV, Fluorogenic
      References
      ReferencesJin, G., et al. 2002. Anal. Biochem. 302, 269.
      Product Information
      ATP CompetitiveN
      FormYellow lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₅₉H₉₃N₂₃O₂₀
      Chemical formulaC₅₉H₉₃N₂₃O₂₀
      ReversibleN
      Quality LevelMQ100
      Biological Information
      Primary TargetFluorogenic decapeptide substrate that is useful for continuous monitoring of TACE activity
      Primary Target IC<sub>50</sub>kcat = 21.6 s-1 and substrate concentration at half the Vmax, S0.5 = 342 µM
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Emission max.
      Excitation max.
      Peptide SequenceAbz-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Dpa
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Global Trade Item Number
      Bestellnummer GTIN
      616407-1MG 04055977185713