566332 Sigma-AldrichSirt1 Inhibitor VII, Inauhzin - Calbiochem
The Sirt1 Inhibitor VII, Inauhzin controls the biological activity of Sirt1. This small molecule/inhibitor is primarily used for Cell Structure applications.
More>> The Sirt1 Inhibitor VII, Inauhzin controls the biological activity of Sirt1. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<Sirt1 Inhibitor VII, Inauhzin - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: 10-[2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)butanoyl]-10H-phenothiazine, INZ
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Übersicht
| Replacement Information |
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Key Spec Table
| Empirical Formula |
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| C₂₅H₁₉N₅OS₂ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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| 566332-10MG |
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Glasflasche | 10 mg |
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| Description | |
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| Overview | A cell-permeable phenothiazine derivative that selectively inhibits SirT1 (IC50 ≤2.0 µM), but not SirT2, SirT3, or HCAC8 (IC50 >50 µM), activity. Effectively elevates cellular p53 lysine acetylation (Effective conc. 2 µM), thereby protecting p53 lysine residues from MDM2-mediated ubiquitination without inhibiting MDM2 activity toward deacetylated p53. Shown to inhibit cancer cell growth in a p53-dependent manner (IC50 = 2.0 and 15.7µM, respectively, against HCT116p53+/+ and HCT116p53-/- cells) and synergize with Nutlin-3 (Cat. Nos. 444143, 444151, & 444152) in blocking HCT116p53+/+ proliferation in vitro (1 µM INZ & 4 µM Nutlin-3) and inducing HCT116p53+/+ apoptosis in mice in vivo (15 mg INZ/kg/d i.p; 150 mg Nut-3/kg/12 h p.o.). |
| Catalogue Number | 566332 |
| Brand Family | Calbiochem® |
| Synonyms | 10-[2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)butanoyl]-10H-phenothiazine, INZ |
| References | |
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| References | Zhang, Q., et al. 2012. EMBO Mol. Med. 4, 298. Zhang, Y., et al. 2012. Cancer Biol. Ther. 13, 915 |
| Product Information | |
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| Form | Beige powder |
| Hill Formula | C₂₅H₁₉N₅OS₂ |
| Chemical formula | C₂₅H₁₉N₅OS₂ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Sirt1 |
| Primary Target IC<sub>50</sub> | 0.7&ndash |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 566332-10MG | 04055977191486 |
Documentation
Sirt1 Inhibitor VII, Inauhzin - Calbiochem SDB
| Titel |
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Sirt1 Inhibitor VII, Inauhzin - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 566332 |
Literatur
| Übersicht |
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| Zhang, Q., et al. 2012. EMBO Mol. Med. 4, 298. Zhang, Y., et al. 2012. Cancer Biol. Ther. 13, 915 |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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