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03-209 SET7/9 human recombinant - Methyltransferase enzyme

Human recombinant SET7/9 expressed in E. Coli.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Key Applications: Enzyme Assays UniProt Number: Q8WTS6
03-209
100 µg  
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      Replacement Information

      Key Spec Table

      Key ApplicationsSpeciesUni Prot Number
      Enzyme AssaysHuman Q8WTS6
      Description
      Catalogue Number03-209
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionSET7/9 human recombinant - Methyltransferase enzyme
      OverviewHuman recombinant SET7/9 expressed in E. Coli
      Background InformationThe methylation of histones plays a pivotal role in the regulation of chromatin structure and gene expression. Histone methylation can occur on Arg or Lys residues, with an exquisite site selectivity for Lys methylation at specific positions in the N-termini of histones H3 and H4. SET7/9, a histone methyltransferase (HMTase), which transfers methyl groups to Lys4 of Histone H3, forms a complex with S-adenosyl-L-methionine. This complex contains an active site consisting of a binding pocket where an AdoMet molecule, in an unusual conformation, binds a narrow substrate-specific channel that only unmethylated lysine residues can access, and a catalytic tyrosine residue.
      References
      Product Information
      FormatPurified
      PresentationIn liquid containing 50 mM Tris-HCl, pH 7.5, containing 0.2 M sodium chloride, 5 mM DTT and 20% glycerol. Frozen solution.
      Quality LevelMQ100
      Applications
      ApplicationHuman recombinant SET7/9 expressed in E. Coli.
      Key Applications
      • Enzyme Assays
      Application NotesMethyltransferase assays
      Biological Information
      Concentration1 mg/mL
      PurityPurity >95% by SDS-PAGE
      Specific Activity<1.0EU/µg protein (LAL test)
      UniProt Number
      Molecular Weight~41 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 12 months at -20°C from date of receipt. Avoid multiple freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      03-209 04053252550867