555550 Sigma-AldrichRho Kinase Inhibitor - Calbiochem
The Rho kinase inhibitor, CAS 871543-07-6, is a cell-permeable, highly specific, reversible, potent, and ATP-competitive inhibitor of Rho-associated kinase (Ki = 1.6 nM).
More>> The Rho kinase inhibitor, CAS 871543-07-6, is a cell-permeable, highly specific, reversible, potent, and ATP-competitive inhibitor of Rho-associated kinase (Ki = 1.6 nM). Less<<Rho Kinase Inhibitor - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: H-1152, H-1152P, (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine, 2HCl, ROCK Inhibitor, Dimethylfasudil (diMF, H-1152P)
Empfohlene Produkte
Übersicht
| Replacement Information |
|---|
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 871543-07-6 | C₁₆H₂₁N₃O₂S • 2HCl |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 555550-1MG |
|
Kst.-Ampulle | 1 mg |
|
— | |
| 555550-5MG |
|
Glasflasche | 5 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, reversible, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK; Ki = 1.6 nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki = 630 nM for PKA, 9.27 μM for PKC, and 10.1 μM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50 = 2.5 μM) in NT-2 cells. Reported to be more potent and selective than Y-27632 (Cat. Nos. 688000 and 688001). Mainly targets Aurora Kinase A, and induces polyploidization of acute megakaryocytic leukemia cells (AMKL). At 10 mM (500 µg/128 µl) solution of Rho Kinase Inhibitor (Cat. No. 555552) in H2O is also available. |
| Catalogue Number | 555550 |
| Brand Family | Calbiochem® |
| Synonyms | H-1152, H-1152P, (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine, 2HCl, ROCK Inhibitor, Dimethylfasudil (diMF, H-1152P) |
| References | |
|---|---|
| References | Wen, Qiang, et al. 2012. Cell 150, 575. Ikenoya, M., et al. 2002. J. Neurochem. 81, 9. Sasaki, Y., et al. 2002. Pharmacol. Ther. 93, 225. |
| Product Information | |
|---|---|
| CAS number | 871543-07-6 |
| ATP Competitive | Y |
| Form | White solid |
| Hill Formula | C₁₆H₂₁N₃O₂S • 2HCl |
| Chemical formula | C₁₆H₂₁N₃O₂S • 2HCl |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | The Rho kinase inhibitor, CAS 871543-07-6, is a cell-permeable, highly specific, reversible, potent, and ATP-competitive inhibitor of Rho-associated kinase (Ki = 1.6 nM). |
| Biological Information | |
|---|---|
| Primary Target | ROCK |
| Primary Target K<sub>i</sub> | 1.6 nM against G-protein Rho-associated kinase |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Bestellnummer | GTIN |
| 555550-1MG | 04055977268393 |
| 555550-5MG | 04055977268409 |
Documentation
Rho Kinase Inhibitor - Calbiochem SDB
| Titel |
|---|
Rho Kinase Inhibitor - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
|---|---|
| 555550 |
Literatur
| Übersicht |
|---|
| Wen, Qiang, et al. 2012. Cell 150, 575. Ikenoya, M., et al. 2002. J. Neurochem. 81, 9. Sasaki, Y., et al. 2002. Pharmacol. Ther. 93, 225. |
Broschüre
| Titel |
|---|
| Bulk Product Guide |