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HTS210RTA Ready-to-Assay™ P2Y2 Purinergic Receptor Frozen Cells

Human P2Y2 GPCR frozen cells for Calcium Flux FLIPR Assays.

Host Cell: 1321N1 Entrez Gene Number: NM_002564.2
HTS210RTA
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      This product requires a User Agreement (Label License). Please see product datasheet for further information

      Key Spec Table

      SpeciesHost CellsProtein Target
      Human 1321N1P2Y2
      Description
      Catalogue NumberHTS210RTA
      Trade Name
      • Ready-to-Assay
      DescriptionReady-to-Assay™ P2Y2 Purinergic Receptor Frozen Cells
      Background InformationMillipore’s Ready-to-Assay GPCR frozen cells are designed for simple, rapid calcium assays with no requirement for intensive cell culturing. Millipore has optimized the freezing conditions to provide cells with high viability and functionality post-thaw. The user simply thaws the cells and resuspends them in media, dispenses cell suspension into assay plates and, following over night recovery, assays for calcium response.

      The P2Y GPCRs serve as receptors for extracellular nucleotides (Abbracchio et al., 2006). P2Y2 (also known as P2U) is activated by UTP and ATP, and couples to Gq to increase intracellular calcium (Parr et al., 1994). The P2Y2 receptor knockout mouse displays defective nucleotide-stimulated Cl- secretion, and a P2Y2 selective agonist increases tracheal epithelial chloride and water secretion (Cressman et al., 1999; Yerxa et al., 2002). As a result, P2Y2 is a potential target for treatment of cystic fibrosis. In addition, the P2Y2 KO mouse displays salt-resistant hypertension (Rieg et al., 2007). Millipore’s cloned human P2Y2-expressing cell line is made in the 1321N1host, which supports high levels of recombinant P2Y2 expression on the cell surface. Thus, the cell line is an ideal tool for screening for agonists and antagonists of P2Y2.
      References
      Product Information
      Components
      • Pack contains 2 vials of mycoplasma-free cells, 1 ml per vial.
      • Fifty (50) mL of Media Component.
      Detection methodFluorescent
      Quality LevelMQ300
      Applications
      ApplicationHuman P2Y2 GPCR frozen cells for Calcium Flux FLIPR Assays.
      Key Applications
      • Calcium Flux Assays
      Biological Information
      Entrez Gene Number
      GPCR ClassA
      Host Cells1321N1
      Protein TargetP2Y2
      Target Sub-FamilyP2Y / Purinergic (metabotropic)
      Cell Line Type
      • GPCR Cell Lines
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges Merck to request certain information about you and the establishment where the GMOs are being handled. Click here for Enduser Declaration (EUD) Form.
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size1 kit
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      HTS210RTA 04053252555329

      Documentation

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      Kategorien

      Life Science Research > Cell Culture and Systems > Cell Lines > GPCR Frozen Cells
      Life Science Research > Drug Discovery and Development > GPCR Cell Lines & Assays > GPCR Frozen Cells