530535 Sigma-AldrichRPA Inhibitor, TDRL-505 - CAS 1785760-75-9 - Calbiochem
A cell-permeable compound that targets human Replication Protein A (RPA) and inhibits its DNA-binding activity (IC₅₀= 12.9 µM).
More>> A cell-permeable compound that targets human Replication Protein A (RPA) and inhibits its DNA-binding activity (IC₅₀= 12.9 µM). Less<<Synonyme: Replication Protein A Inhibitor, Pot1 Inhibitor, Protection of Telemeres Protein 1 Inhibitor, TDRL505
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Übersicht
Key Spec Table
CAS # | Empirical Formula |
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1785760-75-9 | C₂₄H₂₁BrClN₃O₄ |
Preis & Verfügbarkeit
Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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5305350001 |
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Glasflasche | 25 mg |
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Description | |
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Overview | A cell-permeable quinolinyl-dihydropyrazolyl-oxobutanoic acid compound that is shown to target human Replication Protein A (RPA) via primarily the oligosaccharide/oligonucleotide-binding (OB) folds of DNA-bonding domains A & B (DBD-A/B) in the p70 subunit, effectively inhibiting its DNA-binding activity as well as that of Schizosaccharomyces pombe telemere end-binding protein Pot1 (IC50= 12.9 µM and 15.7 µM, respectively), but not Xeroderma pigmentosum group A protein (XPA) involved in the nucleotide excision repair (NER) pathway or E. coli SSB. Reported to induce cell cycle G1-arrest and decrease Annvex V-/PI- healthy cell population (by 50%; 30.8 µM for 48 h) in H460 non-small cell lung carcinoma (NSCLC) cultures with minimal cytotoxicity against freshly isolated human PBMC. Potentiates cisplatin (Cat. No. 232120) and etopside (Cat. No. 341205) cytotoxicity in H460 cultures in a synergistic manner. |
Catalogue Number | 530535 |
Brand Family | Calbiochem® |
Synonyms | Replication Protein A Inhibitor, Pot1 Inhibitor, Protection of Telemeres Protein 1 Inhibitor, TDRL505 |
References | |
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References | Anciano Granadillo, V.J., et al. 2010. J. Nucleic Acids 2010, 304035. Shuck, S.C., and Turchi, J.J. 2010. Cancer Res. 70, 3189. |
Product Information | |
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CAS number | 1785760-75-9 |
Form | Off-white solid |
Hill Formula | C₂₄H₂₁BrClN₃O₄ |
Chemical formula | C₂₄H₂₁BrClN₃O₄ |
Reversible | Y |
Quality Level | MQ100 |
Biological Information | |
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Primary Target | Replication Protein A |
Primary Target IC<sub>50</sub> | 12.9, 15.7 and 30.8 µ |
Purity | ≥97% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Bestellnummer | GTIN |
5305350001 | 04055977260861 |