527450 Sigma-AldrichPKR Inhibitor - CAS 608512-97-6 - Calbiochem
PKR Inhibitor, CAS 608512-97-6, is a potent, ATP-binding site directed PKR inhibitor that blocks RNA-induced PKR autophosphorylation (IC50 = 210 nM). Rescue PKR-dependent translation block.
More>> PKR Inhibitor, CAS 608512-97-6, is a potent, ATP-binding site directed PKR inhibitor that blocks RNA-induced PKR autophosphorylation (IC50 = 210 nM). Rescue PKR-dependent translation block. Less<<Synonyme: PKRi, Double-stranded RNA-dependent Protein Kinase Inhibitor, C16, Double-stranded RNA-activated Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I
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Übersicht
Key Spec Table
CAS # | Empirical Formula |
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608512-97-6 | C₁₃H₈N₄OS |
Preis & Verfügbarkeit
Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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527450-5MG |
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Glasflasche | 5 mg |
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Description | |
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Overview | An imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC50 = 210 nM) and rescue PKR-dependent translation block (IC50 = 100 nM). Inactive control is also available (Cat. No. 527455). Shown to increase the late phase of long-lasting synaptic potentiation, and enhance long-term memory in mice. Also available as a 50 mM solution in DMSO (Cat. No. 527451). |
Catalogue Number | 527450 |
Brand Family | Calbiochem® |
Synonyms | PKRi, Double-stranded RNA-dependent Protein Kinase Inhibitor, C16, Double-stranded RNA-activated Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I |
References | |
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References | Zhu, P.J., et al. 2011. Cell 147, 1384. Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50. |
Product Information | |
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CAS number | 608512-97-6 |
ATP Competitive | N |
Form | Orange to orange brown solid |
Hill Formula | C₁₃H₈N₄OS |
Chemical formula | C₁₃H₈N₄OS |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Primary Target | PKR |
Primary Target IC<sub>50</sub> | 210 nM inhibiting RNA-induced PKR autophosphorylation and 100 nM in rescuing PKR-dependent translation block |
Purity | ≥90% by HPLC |
Physicochemical Information | |
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Cell permeable | N |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Bestellnummer | GTIN |
527450-5MG | 07790788055615 |