528150 Sigma-AldrichPARP Inhibitor VIII, PJ34 - CAS 344458-15-7 - Calbiochem
PARP Inhibitor VIII, PJ34, CAS 344458-15-7, is a cell-permeable, potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM).
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Übersicht
| Replacement Information |
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Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 344458-15-7 | C₁₇H₁₇N₃O₂ · HCl |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 528150-1MG |
|
Kst.-Ampulle | 1 mg |
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| 528150-5MG |
|
Kst.-Ampulle | 5 mg |
|
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| Description | |
|---|---|
| Overview | A cell-permeable, water-soluble phenanthridinone-derivative that acts as a potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350; EC50 = 200 µM). Does not act as an antioxidant at higher concentrations (1 µM to 10 mM). Exhibits neuroprotection in in vivo and in vitro models of stroke. Also available as a 20 mM solution in H2O(Cat. No. 528151). |
| Catalogue Number | 528150 |
| Brand Family | Calbiochem® |
| References | |
|---|---|
| References | Abdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255. Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108. Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561. |
| Product Information | |
|---|---|
| CAS number | 344458-15-7 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₁₇H₁₇N₃O₂ · HCl |
| Chemical formula | C₁₇H₁₇N₃O₂ · HCl |
| Hygroscopic | Hygroscopic |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | PARP Inhibitor VIII, PJ34, CAS 344458-15-7, is a cell-permeable, potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). |
| Biological Information | |
|---|---|
| Primary Target | PARP |
| Primary Target IC<sub>50</sub> | EC50 = 20 nM inhibiting poly(ADP-ribose) polymerase (PARP) |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
|---|---|
| Bestellnummer | GTIN |
| 528150-1MG | 04055977196405 |
| 528150-5MG | 04055977196412 |
Documentation
PARP Inhibitor VIII, PJ34 - CAS 344458-15-7 - Calbiochem SDB
| Titel |
|---|
PARP Inhibitor VIII, PJ34 - CAS 344458-15-7 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
|---|---|
| 528150 |
Literatur
| Übersicht |
|---|
| Abdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255. Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108. Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561. |