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14-699M PAK5 Protein, active, 250 µg

Active, N-terminal 6His-tagged, recombinant, human PAK5, amino acids 425-end. PAK5 is also known as PAK7. For use in Kinase Assays.

PAK5 Protein, active, 250 µg: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
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14-699M
250 µg  Also available in 10 μg size (cat#14-699) and in bulk (cat# 14-699-K).
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      Übersicht

      Replacement Information
      Description
      Catalogue Number14-699M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPAK5 Protein, active, 250 µg
      OverviewN-terminal 6His-tagged, recombinant, human PAK5, amino acids 425-end. PAK5 is also known as PAK7.
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive, N-terminal 6His-tagged, recombinant, human PAK5, amino acids 425-end. PAK5 is also known as PAK7. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed by baculovirus in Sf21 cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described.
      Gene Symbol
      • PAK7
      • PAK-5
      • PAK5
      • MGC26232
      • KIAA1264
      • PAK-7
      Protein TargetPAK5
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilySTE
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9P286 # The activated kinase acts on a variety of targets (By similarity).
      SIZE: 719 amino acids; 80745 Da
      SUBUNIT: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1 (By similarity).
      TISSUE SPECIFICITY: Predominantly expressed in brain.
      PTM: Autophosphorylated when activated by CDC42/p21 (By similarity).
      SIMILARITY: SwissProt: Q9P286 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 CRIB domain. & Contains 1 protein kinase domain.
      Molecular Weight37.4kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of PAKtide
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C from date of shipment
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-699) and in bulk (cat# 14-699-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      14-699M 04053252321030

      Verwandte Produkte & Anwendungen

      Alternative Packsize

      Bestellnummer Beschreibung  
      14-699 PAK5 Protein, active, 10 µg Preis & Verfügbarkeit

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      Kategorien

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases