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499635 OSC Inhibitor, Ro 48-8071 - CAS 189197-69-1 - Calbiochem

The OSC Inhibitor, Ro 48-8071, also referenced under CAS 189197-69-1, controls the biological activity of 2,3-oxidosqualene:lanosterol cyclase activity (OSC).

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 4ʹ-(6-(Allylmethylamino)hexyloxy)-4-bromo-2ʹ-fluorobenzophenone, fumarate

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499635
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
189197-69-1C₂₃H₂₇BrFNO₂• C₄H₄O₄

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      Description
      OverviewAn orally bioavailable benzofuranylallylamine compound that acts as a potent, active site targeting, competitive and reversible inhibitor of 2,3-oxidosqualene:lanosterol cyclase activity (OSC; IC50 ~ 6.5 nM against mammalian) and reduces cholesterol synthesis (IC50 ~ 1.5 nM in HepG2 cells) with minimal buildup of both dioxidosqualene and monooxidosqualene. Downregulates 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase mRNA and synthesis, and exerts less adverse effects in animal models than Statins. Shown to preferentially enhance the DNA-binding affinity of mutant p53 and arrest the growth of human breast cancer cells (IC50 ~ 10 µM).
      Catalogue Number499635
      Brand Family Calbiochem®
      Synonyms4ʹ-(6-(Allylmethylamino)hexyloxy)-4-bromo-2ʹ-fluorobenzophenone, fumarate
      References
      ReferencesThoma, R., et al. 2004. Nature 432, 118.
      Peffley, D.M., et al. 1998. Biochem. Pharmacol. 56, 439.
      Morand, O.H., et al. 1997. J. Lipid Res. 38, 373.
      Product Information
      CAS number189197-69-1
      FormOff-white solid
      Hill FormulaC₂₃H₂₇BrFNO₂• C₄H₄O₄
      Chemical formulaC₂₃H₂₇BrFNO₂• C₄H₄O₄
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      499635-10MG 04055977199284

      Documentation

      OSC Inhibitor, Ro 48-8071 - CAS 189197-69-1 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      OSC Inhibitor, Ro 48-8071 - CAS 189197-69-1 - Calbiochem Analysenzertifikate

      TitelChargennummer
      499635

      Literatur

      Übersicht
      Thoma, R., et al. 2004. Nature 432, 118.
      Peffley, D.M., et al. 1998. Biochem. Pharmacol. 56, 439.
      Morand, O.H., et al. 1997. J. Lipid Res. 38, 373.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-December-2018 JSW
      Synonyms4ʹ-(6-(Allylmethylamino)hexyloxy)-4-bromo-2ʹ-fluorobenzophenone, fumarate
      DescriptionAn orally bioavailable benzofuranylallylamine compound that acts as a potent, active site targeting, competitive and reversible inhibitor of 2,3-oxidosqualene:lanosterol cyclase activity (OSC; IC50 ~6.5 nM against mammalian) and reduces cholesterol synthesis (IC50 ~1.5 nM in HepG2 cells) with minimal buildup of both dioxidosqualene and monooxidosqualene. Downregulates 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase mRNA and synthesis, and exerts less adverse effects in animal models than Statins. Shown to preferentially enhance the DNA-binding affinity of mutant p53 and arrest the growth of human breast cancer cells (IC50 ~10 µM).
      FormOff-white solid
      CAS number189197-69-1
      Chemical formulaC₂₃H₂₇BrFNO₂• C₄H₄O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Regulatory Review
      ReferencesThoma, R., et al. 2004. Nature 432, 118.
      Peffley, D.M., et al. 1998. Biochem. Pharmacol. 56, 439.
      Morand, O.H., et al. 1997. J. Lipid Res. 38, 373.