533718 Sigma-AldrichNOD2 Signaling Inhibitor II, GSK717 - CAS 1595278-21-9 - Calbiochem
A cell-permeable diamide that selectively blocks MDP-stimulated cytokine release and downstream NF-κB and MAPK signaling pathways.
More>> A cell-permeable diamide that selectively blocks MDP-stimulated cytokine release and downstream NF-κB and MAPK signaling pathways. Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: N-(2-(1-(2-(2,3-Dihydro-1H-inden-5-ylamino)-2-oxoethyl)-1H-benzo[d]imidazol-2-yl)ethyl)-N-methylbenzamide, Nucleotide-binding Oligomerization Domain 2 Signaling Inhibitor II, MDP/NOD2-Mediated Signaling Inhibitor, GSK 717
Empfohlene Produkte
Übersicht
| Replacement Information |
|---|
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 5337180001 |
|
Glasflasche | 10 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable benzimidazole diamide compound that acts as a potent, selective, reversible and muramyl dipeptide (MDP)-induced NOD2 (MDP/nucleotide-binding oligomerization domain 2)-mediated signaling inhibitor (IC50 = 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells). Does not affect NOD1, TNFR1, or TLR-2-mediated responses. Also shown to diminish synergy between NOD2 and TLR2. Reduces MDP-stimulated IL-8, IL-6, IL-1β, and TNFα release in primary human monocytes (~5 µM), but does not affect Pam2CSK4-stimulated IL-8 release. Due to a lack of typical activation loop/hinge-binding motif it is unlikely to act as a kinase inhibitor. NOD1 Inhibitor, Nodinitib-1 (Cat. No. 488004) is also available. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. |
| Catalogue Number | 533718 |
| Brand Family | Calbiochem® |
| Synonyms | N-(2-(1-(2-(2,3-Dihydro-1H-inden-5-ylamino)-2-oxoethyl)-1H-benzo[d]imidazol-2-yl)ethyl)-N-methylbenzamide, Nucleotide-binding Oligomerization Domain 2 Signaling Inhibitor II, MDP/NOD2-Mediated Signaling Inhibitor, GSK 717 |
| Description | NOD2 Signaling Inhibitor II, GSK717 |
| References | |
|---|---|
| References | Rickard, D.J., et al. 2013. PLoS ONE.D40 8, e69619. |
| Product Information | |
|---|---|
| CAS number | 1595278-21-9 |
| Form | White solid |
| Hill Formula | C₂₈H₂₈N₄O₂ |
| Chemical formula | C₂₈H₂₈N₄O₂ |
| Reversible | Y |
| Quality Level | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Primary Target | NOD2 |
| Primary Target IC<sub>50</sub> | 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Bestellnummer | GTIN |
| 5337180001 | 04055977286663 |
Documentation
NOD2 Signaling Inhibitor II, GSK717 - CAS 1595278-21-9 - Calbiochem SDB
| Titel |
|---|
NOD2 Signaling Inhibitor II, GSK717 - CAS 1595278-21-9 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
|---|---|
| 533718 |
Literatur
| Übersicht |
|---|
| Rickard, D.J., et al. 2013. PLoS ONE.D40 8, e69619. |
| Datenblatt | ||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
|