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14-676 NLK Protein, active, 10 µg

Active, N-terminal 6His-tagged, recombinant, human NLK, amino acids 121-end, for use in Kinase Assays.

NLK Protein, active, 10 µg: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
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14-676
10 µg  
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      Übersicht

      Replacement Information
      Description
      Catalogue Number14-676
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionNLK Protein, active, 10 µg
      OverviewN-terminal 6His-tagged, recombinant, human NLK, amino acids 121-end
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive, N-terminal 6His-tagged, recombinant, human NLK, amino acids 121-end, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed by baculovirus in Sf21 cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Gene Symbol
      • NLK
      • DKFZp761G1211
      • FLJ21033
      • LAK1
      Protein TargetNLK
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyCMGC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9UBE8 # Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta- catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP (By similarity).
      COFACTOR: Magnesium (By similarity).
      SIZE: 515 amino acids; 57048 Da
      SUBUNIT: Interacts with HIPK2 and MYB.
      SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Note=Predominantly nuclear. A smaller fraction is cytoplasmic (By similarity).
      PTM: Dually phosphorylated on Thr-291 and Tyr-293, which activates the enzyme (By similarity).
      SIMILARITY: SwissProt: Q9UBE8 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.
      Molecular Weight48.7kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of myelin basic protein (Catalog # 13-104)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 6 months at -70°C from date of shipment
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      14-676 04053252580635