480401 Sigma-AldrichNFAT Inhibitor, Cell-Permeable - Calbiochem
The NFAT Inhibitor, Cell-Permeable controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
More>> The NFAT Inhibitor, Cell-Permeable controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications. Less<<NFAT Inhibitor, Cell-Permeable - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: 11R-VIVIT, Nuclear Factor of Activated T cells Inhibitor, RRRRRRRRRRR-GGG-MAGPHPVIVITGPHEE
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Übersicht
| Replacement Information |
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Key Spec Table
| Empirical Formula |
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| C₁₄₇H₂₅₉N₆₇O₃₆S |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 480401-1MG |
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Kst.-Ampulle | 1 mg |
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| Description | |
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| Overview | A cell-permeable version of NFAT Inhibitor (Cat. No. 480402) that is modified at the N-terminal with an eleven arginine transduction domain and a three glycine linker sequence. Prevents the activation and proliferation of T cells both in vitro ( ~ 43% at 1 µM using mixed lymphocyte cultures) and in vivo (10 mg/kg using C3H/HeN mice). Shown to be effective in providing immunosuppression in a murine islet xenograft model. Unlike Cyclosporin A (Cat. No. 239835) and FK506, 11R-VIVIT does not cause side effects outside the immune system as a result of calcineurin (Cat. No. 539568) inhibition and therefore serves as a less toxic alternative for in vivo applications. The functional half-life of 11R-VIVIT has been estimated to be ~30 h in Jurkat cells. |
| Catalogue Number | 480401 |
| Brand Family | Calbiochem® |
| Synonyms | 11R-VIVIT, Nuclear Factor of Activated T cells Inhibitor, RRRRRRRRRRR-GGG-MAGPHPVIVITGPHEE |
| References | |
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| References | Noguchi, H., et al. 2004. Nat. Med. 10, 305. |
| Product Information | |
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| ATP Competitive | N |
| Form | Lyophilized white solid |
| Formulation | Supplied as a trifluoroacetate salt. |
| Hill Formula | C₁₄₇H₂₅₉N₆₇O₃₆S |
| Chemical formula | C₁₄₇H₂₅₉N₆₇O₃₆S |
| Hygroscopic | Hygroscopic |
| Reversible | N |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | NFAT |
| Primary Target IC<sub>50</sub> | Use at 1 µM for preventing the activation and proliferation of T cells |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Peptide Sequence | H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 480401-1MG | 07790788050641 |
Documentation
NFAT Inhibitor, Cell-Permeable - Calbiochem SDB
| Titel |
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NFAT Inhibitor, Cell-Permeable - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 480401 |
Literatur
| Übersicht |
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| Noguchi, H., et al. 2004. Nat. Med. 10, 305. |