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14-700 NEK11 Protein, active, 10 µg

Active, 6His-tagged, recombinant, human full length, NEK11, for use in Kinase Assays.

NEK11 Protein, active, 10 µg: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
14-700
10 µg  
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      Übersicht

      Replacement Information
      Description
      Catalogue Number14-700
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionNEK11 Protein, active, 10 µg
      Overview6His-tagged, recombinant, human full length, NEK11
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive, 6His-tagged, recombinant, human full length, NEK11, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed by baculovirus in Sf21 cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryNEK11 belongs to the NIMA family of kinases, which are involved in DNA replication and genotoxic stress responses (Noguchi et al., 2002 [PubMed 12154088]).[supplied by OMIM]
      Gene Symbol
      • NEK11
      • FLJ23495
      Protein TargetNEK11
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyMisc
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q8NG66 # Possible role in S-phase checkpoint mechanism.
      COFACTOR: Manganese or magnesium.
      SIZE: 645 amino acids; 74162 Da
      SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Note=Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S- arrested cells.
      TISSUE SPECIFICITY: Poorly expressed in cerebellum, trachea, lung, appendix, and uterus.
      DEVELOPMENTAL STAGE: Predominantly expressed at S/G2/M phase.
      PTM: Phosphorylated.
      SIMILARITY: SwissProt: Q8NG66 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. NIMA subfamily. & Contains 1 protein kinase domain.
      Molecular Weight59.3kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of MBP (Catalog # 13-104)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C from date of shipment
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      14-700 04053252282324