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14-542 MKK7β1 Protein, inactive, 50 µg

Inactive, N-terminal GST-tagged, recombinant, human MKK7β1 amino acids 2-end, for use in Kinase Assays.

MKK7β1 Protein, inactive, 50 µg: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
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14-542
50 µg  
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      Replacement Information
      Description
      Catalogue Number14-542
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionMKK7β1 Protein, inactive, 50 µg
      OverviewN-terminal GST-tagged, recombinant, human MKK7β1 amino acids 2-end
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationInactive, N-terminal GST-tagged, recombinant, human MKK7β1 amino acids 2-end, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed in E. coli
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.
      Gene Symbol
      • MAP2K7
      • MKK7
      • PRKMK7
      • MEK7
      • MAPKK7
      • JNKK2
      • Jnkk2
      Protein TargetMKK7β1
      Purification MethodGlutathione-agarose
      Target Sub-FamilySTE
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O14733 # Stress activated, dual specificity kinase that activates the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.
      COFACTOR: Magnesium.
      SIZE: 419 amino acids; 47485 Da
      SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity).
      TISSUE SPECIFICITY: Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.
      PTM: Activated by phosphorylation on Ser/Thr.
      SIMILARITY: SwissProt: O14733 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.
      Molecular Weight74kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of ATF2 (amino acids 19-96)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -20°C
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      14-542 04053252275586