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531068 Lenaldekar (LDK) - CAS 418800-15-4 - Calbiochem

An inhibitor of T cell proliferation (IC₅₀ = 3 µM in CD3+, CD4+, and CD8+ cells). Does not affect other cell types.

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Synonyme: T Cell Proliferation Inhibitor, LDK

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531068
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Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
418800-15-4C₁₈H₁₄N₄

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      Description
      OverviewA quinolinyl hydrazone derived compound that specifically blocks the proliferation of T cells in a dose-dependent manner (IC50 = 3 µM in CD3+, CD4+, and CD8+ cells) without affecting other cell types. Its anti-proliferative effects are non-cytolytic in nature. Induces cell cycle delay at G2/M phase. Selectively induces apoptosis in human leukemic blasts and is shown to be active against all acute lymphoblastic leukemia cell lines (IC50 = 1 -2 µM) and also displays in vivo activity in a zebrafish T-ALL model. Reduces the growth of human T-ALL in murine xenograft models (16 mg/kg, i,p, b.i.d). Also shown to specifically block myelin specific T cell responses and reduce inflammation and demyelination in experimental autoimmune encephalomyelitis, possibly via its interactions with insulin-like growth factor-1 receptor. Diminishes the phosphorylation of T308 and S473 on Akt, however, its action is believed to be upstream of PI-3K/Akt. Does not affect the activity of over 450 other kinases in any significant manner. Exhibits a plasma t1/2 = 2 h.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number531068
      Brand Family Calbiochem®
      SynonymsT Cell Proliferation Inhibitor, LDK
      References
      ReferencesCusick, M.F., et al. 1999. PNAS. 96, 12192.
      Ridges, S, et al. 2012. Blood. 119, 5621.
      Product Information
      CAS number418800-15-4
      FormYellow powder
      Hill FormulaC₁₈H₁₄N₄
      Chemical formulaC₁₈H₁₄N₄
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target IC<sub>50</sub>3 µM to block proliferation of T lymphocytes
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5310680001 04055977242560

      Documentation

      Lenaldekar (LDK) - CAS 418800-15-4 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Cusick, M.F., et al. 1999. PNAS. 96, 12192.
      Ridges, S, et al. 2012. Blood. 119, 5621.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-August-2014 JSW
      SynonymsT Cell Proliferation Inhibitor, LDK
      DescriptionA quinolinyl hydrazone derived compound that specifically blocks the proliferation of T cells in a dose-dependent manner (IC50 = 3 µM in CD3+, CD4+, and CD8+ cells) without affecting other cell types. Its anti-proliferative effects are non-cytolytic in nature. Induces cell cycle delay at G2/M phase. Selectively induces apoptosis in human leukemic blasts and is shown to be active against all acute lymphoblastic leukemia cell lines (IC50 = 1 -2 µM) and also displays in vivo activity in a zebrafish T-ALL model. Reduces the growth of human T-ALL in murine xenograft models (16 mg/kg, i,p, b.i.d). Also shown to specifically block myelin specific T cell responses and reduce inflammation and demyelination in experimental autoimmune encephalomyelitis, possibly via its interactions with insulin-like growth factor-1 receptor. Diminishes the phosphorylation of T308 and S473 on Akt, however, its action is believed to be upstream of PI-3K/Akt. Does not affect the activity of over 450 other kinases in any significant manner. Exhibits a plasma t1/2 = 2 h.
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number418800-15-4
      Chemical formulaC₁₈H₁₄N₄
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesCusick, M.F., et al. 1999. PNAS. 96, 12192.
      Ridges, S, et al. 2012. Blood. 119, 5621.