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508438 Lamellipodial Growth Promoter, C8N6 BPA Polyamine - CAS 870087-09-5 - Calbiochem

A cell-permeable, fast acting, branched polyamine. Induces growth of actin-enriched lamellipodia within minutes without the need for serum cofactors .

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Synonyme: Actin Regulator, C8N6 BPA polyamine, Lamellipodial Enhancer, C8N6 BPA polyamine

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508438
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Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
870087-09-5C₂₀H₄₈N₆·6HCl

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      Description
      OverviewA cell-permeable, fast acting, branched polyamine (C8N6) that specifically induces the growth of actin-enriched lamellipodia within minutes (at ~10-100 µM) without the need for serum cofactors . Its effects are more pronounced on the edges of cells that exhibit lamellipodial activity before any treatment. Enhances nucleation by capping protein and thereby facilitates the initiation of filament branching at the lamellipodium tip. Does not affect actin polymerization in cells pre-treated with depolymerizing agents. Does not affect the survival or death of tumor cells even at higher concentration (1 mM). The assembly of actin appears to be more distinct at physiological ionic concentrations.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number508438
      Brand Family Calbiochem®
      SynonymsActin Regulator, C8N6 BPA polyamine, Lamellipodial Enhancer, C8N6 BPA polyamine
      References
      ReferencesNedeva, I., et al. 2013. Nat. Commun. 4, 2165.
      Product Information
      CAS number870087-09-5
      FormOff-white solid
      Hill FormulaC₂₀H₄₈N₆·6HCl
      Chemical formulaC₂₀H₄₈N₆·6HCl
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by NMR
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5084380001 04055977261974

      Documentation

      Lamellipodial Growth Promoter, C8N6 BPA Polyamine - CAS 870087-09-5 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Nedeva, I., et al. 2013. Nat. Commun. 4, 2165.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-July-2024 JSW
      SynonymsActin Regulator, C8N6 BPA polyamine, Lamellipodial Enhancer, C8N6 BPA polyamine
      DescriptionA cell-permeable, fast acting, branched polyamine (C8N6) that specifically induces the growth of actin-enriched lamellipodia within minutes (at ~ 10-100 µM) without the need for serum cofactors . Its effects are more pronounced on the edges of cells that exhibit lamellipodial activity before any treatment. Enhances nucleation by capping protein and thereby facilitates the initiation of filament branching at the lamellipodium tip. Does not affect actin polymerization in cells pre-treated with depolymerizing agents. Does not affect the survival or death of tumor cells even at higher concentration (1 mM). The assembly of actin appears to be more distinct at physiological ionic concentrations. The Cy3 conjugated version is also available (Cat. No. xxxx?)
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number870087-09-5
      Chemical formulaC₂₀H₄₈N₆·6HCl
      Purity≥95% by NMR
      SolubilityDMSO (50 mg/ml) or H₂O (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesNedeva, I., et al. 2013. Nat. Commun. 4, 2165.