420361 Sigma-AldrichKMO Inhibitor II, JM6 - Calbiochem
The KMO Inhibitor II, JM6 controls the biological activity of KMO. This small molecule/inhibitor is primarily used for Neuroscience applications.
More>> The KMO Inhibitor II, JM6 controls the biological activity of KMO. This small molecule/inhibitor is primarily used for Neuroscience applications. Less<<KMO Inhibitor II, JM6 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: Kynurenine-3-Monooxygenase Inhibitor II, JM6, Kynurenine-3-Hydroxylase Inhibitor II, JM6, 2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-nitrophenyl)-5-(piperidin-1-yl)methylthiazole, KMO Inhibitor I, Ro 61-8048 Prodrug
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Übersicht
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Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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| 420361-10MG |
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Glasflasche | 10 mg |
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| Description | |
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| Overview | An orally bioavailable in-vivo prodrug of KMO Inhibitor I, Ro 61-8048 (Cat. No. 420360) that is shown to be metabolically unstable and slowly release Ro 61-8048 in blood and act as a neuroprotectant. Blocks KMO peripherally (IC50 = 4 µM) and sustainingly elevates kynurenic acid (KYNA) brain levels, an antagonist of excitatory amino acid receptors. Shown to prevent synaptic loss and behavioral deficits in AD and HD mouse model and increase the survival. |
| Catalogue Number | 420361 |
| Brand Family | Calbiochem® |
| Synonyms | Kynurenine-3-Monooxygenase Inhibitor II, JM6, Kynurenine-3-Hydroxylase Inhibitor II, JM6, 2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-nitrophenyl)-5-(piperidin-1-yl)methylthiazole, KMO Inhibitor I, Ro 61-8048 Prodrug |
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| References | Campesan, S., et al. 2011. Chem. Biol. 21, 961. Zwilling, D., et al. 2011. Cell 145, 863. |
| Product Information | |
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| Form | Yellow powder |
| Hill Formula | C₂₃H₂₆N₄O₆S₂ |
| Chemical formula | C₂₃H₂₆N₄O₆S₂ |
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| Quality Level | MQ100 |
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| Purity | ≥97% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Bestellnummer | GTIN |
| 420361-10MG | 04055977187564 |
Documentation
KMO Inhibitor II, JM6 - Calbiochem SDB
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KMO Inhibitor II, JM6 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 420361 |
Literatur
| Übersicht |
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| Campesan, S., et al. 2011. Chem. Biol. 21, 961. Zwilling, D., et al. 2011. Cell 145, 863. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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