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586006 InSolution™ Thapsigargin - CAS 67526-95-8 - Calbiochem

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Synonyme: (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-Acetoxy-4-(butyryloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-((Z)-2-methylbut-2-enoyloxy)-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate

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586006
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586006-2MG
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      Description
      Catalogue Number586006
      Brand Family Calbiochem®
      Synonyms(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-Acetoxy-4-(butyryloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-((Z)-2-methylbut-2-enoyloxy)-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate
      References
      ReferencesWon, J.G. and Orth, D.N. 1995. Endocrinology 136, 5399. Tepel, M., et al. 1994. Biochim. Biophys. Acta 1220, 248. Begum, N., et al. 1993. J. Biol. Chem. 268, 3352. Low, A.M., et al. 1993. Eur. J. Pharmacol. 230, 53. Tsukamoto, A. and Karneko, Y. 1993. Cell. Biol. Int. 17, 969. Wong, W.L., et al. 1993. Biochem. J. 289, 71. Glennon, M.C., et al. 1992. J. Biol. Chem. 267, 25568. Xu, Y., et al. 1992. J. Neurochem. 59, 2224. Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856. Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 2466.
      Product Information
      CAS number67526-95-8
      FormLiquid
      FormulationA 10 mM (2 mg/307 µL) solution of Thapsigargin (Cat. No. 586005) in DMSO.
      Hill FormulaC₃₄H₅₀O₁₂
      Chemical formulaC₃₄H₅₀O₁₂
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      586006-2MG 04055977265033

      Documentation

      InSolution™ Thapsigargin - CAS 67526-95-8 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      InSolution™ Thapsigargin - CAS 67526-95-8 - Calbiochem Analysenzertifikate

      TitelChargennummer
      586006

      Literatur

      Übersicht
      Won, J.G. and Orth, D.N. 1995. Endocrinology 136, 5399. Tepel, M., et al. 1994. Biochim. Biophys. Acta 1220, 248. Begum, N., et al. 1993. J. Biol. Chem. 268, 3352. Low, A.M., et al. 1993. Eur. J. Pharmacol. 230, 53. Tsukamoto, A. and Karneko, Y. 1993. Cell. Biol. Int. 17, 969. Wong, W.L., et al. 1993. Biochem. J. 289, 71. Glennon, M.C., et al. 1992. J. Biol. Chem. 267, 25568. Xu, Y., et al. 1992. J. Neurochem. 59, 2224. Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856. Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 2466.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2013 JSW
      Synonyms(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-Acetoxy-4-(butyryloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-((Z)-2-methylbut-2-enoyloxy)-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate
      Description cell-permeable tumor-promoting sesquiterpene lactone that releases Ca2+ by inhibiting endoplasmic reticular Ca2+-ATPase (IC50 = 4 - 13 nM). Does not increase inositol phosphates and has no significant effect on protein kinase C. Increases Ca2+-dependent Na+ influx in human platelets in a dose-dependent manner. Activates apoptosis in rat thymocytes and induces apoptosis in human hepatoma cells.Specifically inhibits the fusion of autophagosomes with lysosomes, and induces autophagy.
      FormLiquid
      FormulationA 10 mM (2 mg/307 µL) solution of Thapsigargin (Cat. No. 586005) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number67526-95-8
      Chemical formulaC₃₄H₅₀O₁₂
      Structure formulaStructure formula
      Purity≥97% by TLC
      Storage Protect from light
      Avoid freeze/thaw
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Toxicity Irritant
      ReferencesWon, J.G. and Orth, D.N. 1995. Endocrinology 136, 5399. Tepel, M., et al. 1994. Biochim. Biophys. Acta 1220, 248. Begum, N., et al. 1993. J. Biol. Chem. 268, 3352. Low, A.M., et al. 1993. Eur. J. Pharmacol. 230, 53. Tsukamoto, A. and Karneko, Y. 1993. Cell. Biol. Int. 17, 969. Wong, W.L., et al. 1993. Biochem. J. 289, 71. Glennon, M.C., et al. 1992. J. Biol. Chem. 267, 25568. Xu, Y., et al. 1992. J. Neurochem. 59, 2224. Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856. Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 2466.