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400084 HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: Adaptaquin

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400084
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
385786-48-1C₂₁H₁₆ClN₃O₂

Preis & Verfügbarkeit

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400084-10MG
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      Description
      OverviewA cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC50 = 2 µM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase. This compound (5 µM) is shown to significantly stabilize HIF-1α in vitro and upregulate known HIF target genes, Epo and VEGF, in SH-SY5Y human neuroblastoma cell lines. It also exerts a neuroprotective effect (IC50 = 0.25 µM in an oxidative stress model using cortical neurons.
      Catalogue Number400084
      Brand Family Calbiochem®
      SynonymsAdaptaquin
      References
      ReferencesSmirnova, N.A., et al. 2010. Chem. Biol. 4, 380.
      Product Information
      CAS number385786-48-1
      FormTan solid
      Hill FormulaC₂₁H₁₆ClN₃O₂
      Chemical formulaC₂₁H₁₆ClN₃O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      400084-10MG 04055977212327

      Documentation

      HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem Analysenzertifikate

      TitelChargennummer
      400084

      Literatur

      Übersicht
      Smirnova, N.A., et al. 2010. Chem. Biol. 4, 380.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-April-2022 JSW
      SynonymsAdaptaquin
      DescriptionA cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC50 = 2 µM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase. This compound (5 µM) is shown to significantly stabilize HIF-1α in vitro and upregulate known HIF target genes, Epo and VEGF, in SH-SY5Y human neuroblastoma cell lines. It also exerts a neuroprotective effect (IC50 = 0.25 µM in an oxidative stress model using cortical neurons.
      FormTan solid
      CAS number385786-48-1
      Chemical formulaC₂₁H₁₆ClN₃O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSmirnova, N.A., et al. 2010. Chem. Biol. 4, 380.