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14-669 DYRK2 Protein, active, 10 µg

Active, 6His-tagged, recombinant, full length human DYRK2, for use in Kinase Assays.

DYRK2 Protein, active, 10 µg: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
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14-669
10 µg  
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      Übersicht

      Replacement Information
      Description
      Catalogue Number14-669
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionDYRK2 Protein, active, 10 µg
      Overview6His-tagged, recombinant, full length human DYRK2
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive, 6His-tagged, recombinant, full length human DYRK2, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed by baculovirus in Sf21 cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryDYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert.
      Gene Symbol
      • DYRK2
      • FLJ21365
      • FLJ21217
      Protein TargetDYRK2
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyCMGC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q92630 # Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.
      COFACTOR: Magnesium. & Manganese.
      SIZE: 601 amino acids; 66652 Da
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocates into the nucleus following DNA damage.
      TISSUE SPECIFICITY: Testis, after the onset of spermatogenesis.
      PTM: Phosphorylated on serine/threonine residues (By similarity).
      SIMILARITY: SwissProt: Q92630 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. & Contains 1 protein kinase domain.
      Molecular Weight63.5kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of casein
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      14-669 04053252744945