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239819 CXCR2 antagonist, Cpd 19 - CAS 473728-67-5 - Calbiochem

The CXCR2 antagonist, Cpd 19, also referenced under CAS 473728-67-5, controls the biological activity of CXCR2.

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Synonyme: 3-(2-(cyclopentylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide

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239819
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
473728-67-5C₁₈H₂₁N₃O₄

Preis & Verfügbarkeit

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239819-2MG
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      Description
      OverviewA cell-permeable, cyclobutenedione derivative that acts as a potent antagonist of chemokine receptor CXCR2 (IL8RB) (IC50 = 8 nM). Reported to inhibit CXCR2-mediated chemotaxis in a CXCR2 expressing cell line (IC50 = 145 nM). Exhibits good stability in human and rat liver microsomal preparations (> 50% remaining after 30 min at 37°C).
      Catalogue Number239819
      Brand Family Calbiochem®
      Synonyms3-(2-(cyclopentylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide
      Application Data
      References
      ReferencesMerritt, J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 4107.
      Product Information
      CAS number473728-67-5
      FormOff-white solid
      Hill FormulaC₁₈H₂₁N₃O₄
      Chemical formulaC₁₈H₂₁N₃O₄
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      239819-2MG 04055977198935

      Documentation

      CXCR2 antagonist, Cpd 19 - CAS 473728-67-5 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      CXCR2 antagonist, Cpd 19 - CAS 473728-67-5 - Calbiochem Analysenzertifikate

      TitelChargennummer
      239819

      Literatur

      Übersicht
      Merritt, J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 4107.

      Broschüre

      Titel
      New Products: Volume 3, 2012
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-July-2014 JSW
      Synonyms3-(2-(cyclopentylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide
      Application Data
      DescriptionA cell-permeable, cyclobutenedione derivative that acts as a potent antagonist of chemokine receptor CXCR2 (IL8RB) (IC50 = 8 nM). Reported to inhibit CXCR2-mediated chemotaxis in a CXCR2 expressing cell line (IC50 = 145 nM). Exhibits good stability in human and rat liver microsomal preparations (> 50% remaining after 30 min at 37°C).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number473728-67-5
      Chemical formulaC₁₈H₂₁N₃O₄
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml; light brown solution)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Regulatory Review
      ReferencesMerritt, J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 4107.