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205530 CA-074 - Calbiochem

CA-074, also referenced under CAS 134448-10-5, modulates the biological activity of cathepsin B. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

CA-074 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: Cathepsin B Inhibitor III, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline

Primary Target: cathepsin B
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205530
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

Empirical Formula
C₁₈H₂₉N₃O₆

Preis & Verfügbarkeit

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205530-1MG
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      Description
      OverviewAn epoxysuccinyl peptide that acts as a potent, irreversible, and specific inhibitor of cathepsin B (IC50 = 2.24 nM for rat liver cathepsin B). Reduces ischemia-induced neuronal death. Exhibits lower membrane permeability when compared to CA-074 Me (Cat. No. 205531).
      Catalogue Number205530
      Brand Family Calbiochem®
      SynonymsCathepsin B Inhibitor III, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline
      References
      ReferencesChan, V.J., et al. 1999. Biochem. J. 340, 113.
      Tsuchiya, K., et al. 1999. Exp. Neurol. 155, 187.
      Yamamoto, A., et al. 1997. J. Biochem. 121, 974.
      Inubushi, T., et al. 1994. J. Biochem. 116, 282.
      Murata, M., et al. 1991. FEBS Lett. 280, 307.
      Towatari, T., et al. 1991. FEBS Lett. 280, 311.
      Product Information
      ATP CompetitiveN
      FormColorless or white solid
      Hill FormulaC₁₈H₂₉N₃O₆
      Chemical formulaC₁₈H₂₉N₃O₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcathepsin B
      Primary Target IC<sub>50</sub>2.24 nM for rat liver cathepsin B
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      205530-1MG 04055977219616

      Documentation

      CA-074 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      CA-074 - Calbiochem Analysenzertifikate

      TitelChargennummer
      205530

      Literatur

      Übersicht
      Chan, V.J., et al. 1999. Biochem. J. 340, 113.
      Tsuchiya, K., et al. 1999. Exp. Neurol. 155, 187.
      Yamamoto, A., et al. 1997. J. Biochem. 121, 974.
      Inubushi, T., et al. 1994. J. Biochem. 116, 282.
      Murata, M., et al. 1991. FEBS Lett. 280, 307.
      Towatari, T., et al. 1991. FEBS Lett. 280, 311.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-May-2008 RFH
      SynonymsCathepsin B Inhibitor III, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline
      DescriptionA potent, irreversible inhibitor of Cathepsin B in vivo and in vitro (IC50 = 2.24 nM for rat liver cathepsin B).
      FormColorless or white solid
      Chemical formulaC₁₈H₂₉N₃O₆
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesChan, V.J., et al. 1999. Biochem. J. 340, 113.
      Tsuchiya, K., et al. 1999. Exp. Neurol. 155, 187.
      Yamamoto, A., et al. 1997. J. Biochem. 121, 974.
      Inubushi, T., et al. 1994. J. Biochem. 116, 282.
      Murata, M., et al. 1991. FEBS Lett. 280, 307.
      Towatari, T., et al. 1991. FEBS Lett. 280, 311.