203290 Sigma-AldrichBisindolylmaleimide I - CAS 133052-90-1 - Calbiochem
Bisindolylmaleimide I, CAS 133052-90-1, is a cell-permeable, highly selective, reversible inhibitor of protein kinase C (IC50 = 10 nM). Acts on the ATP-binding site of PKC.
More>> Bisindolylmaleimide I, CAS 133052-90-1, is a cell-permeable, highly selective, reversible inhibitor of protein kinase C (IC50 = 10 nM). Acts on the ATP-binding site of PKC. Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-maleimide, Gö 6850, GF 109203X
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
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| 133052-90-1 | C₂₅H₂₄N₄O₂ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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| 203290-1MG |
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Kst.-Ampulle | 1 mg |
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| 203290-250UG |
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Kst.-Ampulle | 250 μg |
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| Description | |
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| Overview | A highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor (IC50 = 10 nM) that is structurally similar to staurosporine. Acts as a competitive inhibitor for the ATP-binding site of PKC. Shows high selectivity for PKCα-, βI-, βII-, γ-, δ-, and ε- isozymes. Potently inhibits GSK-3 in primary adipocyte lysates (IC50 = 360 nM) and in GSK-3β immunoprecipitates (IC50 = 170 nM). May inhibit protein kinase A at a much higher concentration (IC50 = 2 µM). A 1 mg/ml solution of Bisindolylmaleimide I (Cat. No. 203293) in anhydrous DMSO is also available. |
| Catalogue Number | 203290 |
| Brand Family | Calbiochem® |
| Synonyms | 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-maleimide, Gö 6850, GF 109203X |
| Product Information | |
|---|---|
| CAS number | 133052-90-1 |
| ATP Competitive | Y |
| Form | Deep orange solid |
| Hill Formula | C₂₅H₂₄N₄O₂ |
| Chemical formula | C₂₅H₂₄N₄O₂ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
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| Application | Bisindolylmaleimide I, CAS 133052-90-1, is a cell-permeable, highly selective, reversible inhibitor of protein kinase C (IC50 = 10 nM). Acts on the ATP-binding site of PKC. |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 203290-1MG | 04055977221121 |
| 203290-250UG | 07790788048327 |
Documentation
Bisindolylmaleimide I - CAS 133052-90-1 - Calbiochem SDB
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Bisindolylmaleimide I - CAS 133052-90-1 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 203290 |
Literatur
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| Hers, I., et al. 1999. FEBS Lett. 460, 433. Ku, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730. Gekeler, V., et al. 1996. Br. J. Cancer 74, 897. Kiss, Z., et al. 1995. Biochim. Biophys. Acta 1265, 93. Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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