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07-1840 Anti-phospho-Acinus (Ser422) Antibody

Use Anti-phospho-Acinus (Ser422) Antibody (rabbit polyclonal antibody) validated in WB to detect phospho-Acinus (Ser422) also known as apoptotic chromatin condensation inducer 1, functional spliceosome-associated protein 152.

Research Category: Epigenetics & Nuclear Function, Epigenetics & Nuclear Function Research Sub-Category: Apoptosis - Additional, Chromatin Biology Gene Symbol: ACIN1, ACINUS, CAN, Acinus UniProt Number: Q9UKV3
07-1840
100 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, H, MWBRbSerumPolyclonal Antibody
      Description
      Catalogue Number07-1840
      DescriptionAnti-phospho-Acinus (Ser422) Antibody
      Alternate Names
      • apoptotic chromatin condensation inducer 1
      • apoptotic chromatin condensation inducer in the nucleus
      • functional spliceosome-associated protein 152
      Background InformationAcinus (Apoptotic Chromatin condensation Inducer in the Nucleus) is a ubiquitously expressed nuclear factor essential for apoptotic chromatin condensation. The ~220 kDa acinus protein is cleaved by caspase-3 and an additional unidentified protease. This protelytic cleavage releases a 17 kDa fragment to induce chromatin condensation. Acinus is expressed in three isoforms, AcinusL, AcinusS, and AcinusS' with the two shorter isoforms corresponding to the C-terminal region of the longer form.
      References
      Product Information
      FormatSerum
      Control
      • NGF treated and untreated PC12 cell lysate
      PresentationUnpurified rabbit polyclonal containing serum with 0.05% sodium azide.
      Applications
      ApplicationUse Anti-phospho-Acinus (Ser422) Antibody (rabbit polyclonal antibody) validated in WB to detect phospho-Acinus (Ser422) also known as apoptotic chromatin condensation inducer 1, functional spliceosome-associated protein 152.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Acinus phosphorylated at Ser422.
      EpitopePhosphorylated Ser422
      HostRabbit
      SpecificityRecognizes Acinus phosphorylated at Ser422.
      IsotypeIgG
      Species Reactivity
      • Rat
      • Human
      • Mouse
      Species Reactivity NoteDemonstrated to react with rat. Predicted to react with human and mouse based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ACIN1
      • ACINUS
      • CAN
      • Acinus
      Modifications
      • Phosphorylation
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: Induces apoptotic chromatin condensation after activation by CASP3.

      SIZE: 1341 amino acids; 151888 Da

      SUBCELLULAR LOCATION: Nucleus.

      TISSUE SPECIFICITY: Ubiquitous.

      PTM: Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.

      SIMILARITY: Contains 1 SAP domain.
      Molecular WeightThe molecular weight of phospho-Acinus-L is ~ 220 kDa, phospho-Acinus-S' and S are ~ 100 kDa. The caspase degraded form is approximately 58 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in NGF treated and untreated PC12 cell lysate.

      Western Blot Analysis:1:1,000 dilution of this antibody detected Acinus on 10 µg of NGF treated and untreated PC12 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      07-1840 04053252274015

      Documentation