Millipore Sigma Vibrant Logo

MABS2310-25UG Anti-TROP2 Antibody, clone TrMab-29

Anti-TROP2, clone TrMab-29, Cat. No. MABS2310, is a mouse monoclonal antibody that detects TROP2 and is tested for use in Flow Cytometry, Immunohistochemistry, and Western Blotting.

View Products on Sigmaaldrich.com
MABS2310-25UG
25 μg  
Preis wird abgerufen...
Preis nicht abrufbar
Die Mindestmenge muss ein Vielfaches sein von
Maximum Quantity is
Bei Bestätigung Weitere Informationen
Sie haben () gespart
 
—
Bitte erfragen
—
Eingeschränkte Verfügbarkeit Eingeschränkte Verfügbarkeit
Lieferbar 
Produkt wurde eingestellt
Begrenzter Lagerbestand
Bestätigung der Verfügbarkeit erforderlich
    Restmenge: Angebot folgt
      Restmenge: Angebot folgt
      Bitte erfragen
      Kontakt zum Kundenservice
      Contact Customer Service

       

      Kontakt zum Kundenservice

      Übersicht

      Replacement Information
      Description
      Catalogue NumberMABS2310-25UG
      DescriptionAnti-TROP2 Antibody, clone TrMab-29
      Alternate Names
      • Tumor-associated calcium signal transducer 2
      • Cell surface glycoprotein Trop-2
      • Membrane component chromosome 1 surface marker 1
      • Pancreatic carcinoma marker protein GA733-1
      Background InformationTumor-associated calcium signal transducer 2 (UniProt: P09758; also known as Cell surface glycoprotein Trop-2, Trophoblast antigen 2, Membrane component chromosome 1 surface marker 1, Pancreatic carcinoma marker protein GA733-1) is encoded by the TACSTD2 (also known as GA733-1, M1S1, TROP2) gene (Gene ID: 4070) in human. TROP2 is a single-pass type 1 membrane glycoprotein that is synthesized with a signal peptide (aa 1-26), which is subsequently cleaved off to generate the mature form that contains an extracellular domain (aa 27-274), a transmembrane domain (aa 275-297), and a cytoplasmic domain (aa 298-323). It contains both extracellular epidermal growth factor-like and thyroglobulin type-1 repeat domains. Its expression is observed in placenta and is highly expressed in many cancers where it plays a role in tumor progression. About 85% of all solid cancers display increased expression of TROP2. Its expression is also reported in stem cells in various tissues. TROP2 expression in cancer cells has been correlated with drug resistance. Upregulation of TROP2 is reported to drive the expression and activation of CREB1, Jun, NF-kB, Rb, STAT1, and STAT3 through induction of the cyclin D1 and the ERK pathways. Mutations in TACSTD2 is known to cause corneal dystrophy of the gelatinous drop-like type (GDLD), an autosomal recessive disorder that is characterized by pathognomonic branching lattice figures in the cornea leading to blindness. (Ref.: Sayama, Y., et al. (2021). Biochem. Biophys. Rep. 25; 100902; Anna Shvartsur, A., and Bonavida, B. (2015). Genes Cancer. 6(3-4); 84-105).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ200
      Applications
      ApplicationAnti-TROP2, clone TrMab-29, Cat. No. MABS2310, is a mouse monoclonal antibody that detects TROP2 and is tested for use in Flow Cytometry, Immunohistochemistry, and Western Blotting.
      Key Applications
      • Western Blotting
      • Flow Cytometry
      • Immunohistochemistry (Paraffin)
      Application NotesTested Applications

      Immunohistochemistry (Paraffin) Analysis: A representative lot detected TROP2 in Immunohistochemistry applications (Sayama, Y., et al. (2021). Biochem Biophys Rep. 25: 100902).

      Western Blotting Analysis: A representative lot detected TROP2 in Western Blotting applications (Sayama, Y., et al. (2021). Biochem Biophys Rep. 25: 100902).

      Flow Cytometry Analysis: A representative lot detected TROP2 in Flow Cytometry applications (Sayama, Y., et al. (2021). Biochem Biophys Rep. 25: 100902).

      Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user
      Biological Information
      ImmunogenCHO K1 cells overexpressing TROP2-PA and PA-TROP2-RAP-MAP.
      EpitopeUnknown
      CloneTrMab-29
      Concentration1.0 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
      HostMouse
      SpecificityClone TrMab-29 is a mouse monoclonal antibody that detects Tumor-associated calcium signal transducer 2 TROP2).
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TACSTD2
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight~38 kDa observed; 35.71 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in lysate from CHO-K1 cells overexpressing TROP2.

      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected TROP2 in lysate from CHO-K1 cells overexpressing TROP2
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsRecommended storage: +2°C to +8°C.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABS2310-25UG 04065268364505