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AB9274-200UL Anti-Sodium Channel Nav1.8 Antibody, pain

This Anti-Sodium Channel Nav1.8 Antibody, pain is validated for use in WB for the detection of Sodium Channel Nav1.8.

Anti-Sodium Channel Nav1.8 Antibody, pain: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: SCN10A, PN3, Nav1.8, SNS, hPN3 UniProt Number: Q9Y5Y9
AB9274-200UL
200 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB9274-200UL
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Sodium Channel Nav1.8 Antibody, pain
      Alternate Names
      • SNS
      • SCN10A
      • PN3
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Sodium Channel Nav1.8 Antibody, pain is validated for use in WB for the detection of Sodium Channel Nav1.8.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:200 using ECL on rat DRG lysate.

      Dilutions should be made using a carrier protein such as BSA (1-3%)

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide from rat Nav1.8 (Accession Q63554). The immunogen sequence is 14/15 residues identical in mouse and 7/15 residues identical in human.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityNav1.8 (SNS, SCN10A, PN3)
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryVoltage-gated sodium channels are integral membrane glycoproteins that are responsible for the initial rising phase of action in most excitable cells. They are composed of a large alpha subunit that may be associated with one or more smaller beta subunits. Sodium channels can be differentiated by their primary structure, kinetics, and relative sensitivity to the neurotoxin tetrodotoxin (TTX). Sodium channels, particularly those with TTX-resistant currents, have been found to accumulate in the region of peripheral nerve injury and may be important in chronic pain. SCN10A encodes a TTX-resistant channel that is restricted to the peripheral sensory nervous system (Rabert et al., 1998 [PubMed 9839820]).[supplied by OMIM]
      Gene Symbol
      • SCN10A
      • PN3
      • Nav1.8
      • SNS
      • hPN3
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9Y5Y9 # This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms (By similarity).
      SIZE: 1956 amino acids; 220566 Da
      SUBUNIT: The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B. Found in a number of complexes with PRX, TCTEL1 and PDZK3. Interacts with proteins such as FSTL1, PRX, TCTEL1, PDZK3, S100A10 and many others (By similarity). Interacts with NEDD4 and NEDD4L.
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By similarity). Note=It can be translocated to the extracellular membrane through association with S100A10 (By similarity).TISSUE SPECIFICITY: Expressed in the dorsal root ganglia and sciatic nerve.
      DOMAIN: SwissProt: Q9Y5Y9 The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
      PTM: Ubiquitinated by NEDD4L; which promotes its endocytosis (By similarity).
      SIMILARITY: Belongs to the sodium channel family. & Contains 1 IQ domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      AB9274-200UL 04053252509032