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MABF3081-25UG Anti-SLAMF6/NTB-A Antibody, clone NT-7

Anti-SLAMF6/NTB-A, clone NT-7 , Cat. No. MABF3081, is a mouse monoclonal antibody that detects NTB-A/CD352 and is tested for use in Flow Cytometry and ELISA.

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25 μg  
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      Übersicht

      Replacement Information
      Description
      Catalogue NumberMABF3081-25UG
      DescriptionAnti-SLAMF6/NTB-A Antibody, clone NT-7
      Alternate Names
      • SLAM family member 6
      • Activating NK receptor
      • NK-T-B-antigen (NTB-A)
      • CD352
      • Lymphocyte antigen 108
      Background InformationSLAM family member 6 (UniProt: Q96DU3; also known as Activating NK receptor, NK-T-B-antigen (NTB-A), CD352) is encoded by the SLAMF6 (also known as KALI) gene (Gene ID: 114836) in human. SLAMF6 belongs to the 7-member signaling lymphocytic activation molecule family (SLAMF) of receptors broadly expressed in hematopoietic cells. SLAM receptors triggered by homo or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. SLAMF members carry one or more copies of immunoreceptor tyrosine-based switch motif or ITSM (T-X-Y-X-X-[VI]) in their cytoplasmic tails. Upon phosphorylation on the tyrosine residue, ITSM mediates the recruitment of SH2 domain-containing signaling molecules such as SLAM-associated protein (SAP), including SAP in T-, NK, and NK T-cells, EAT-2A and EAT-2B (murine) in NK cells and APCs. SLAMF6/NTB-A is predominantly localized to the cell membrane and is a single-pass type I membrane protein and is synthesized with a signal peptide sequence (aa 1-21), the removal of which yields the mature SLAMF6 with an extracellular domain (aa 22-226), a transmembrane domain (aa 227-247) and, a cytoplasmic domain (aa 248-331). Its expression is primarily observed in cells of the immune system. SLAMF6/NTB-A is a receptor on the surfaces of human NK, T, and B cells, mediating a signal whose malfunction may be involved in X-linked lymphoproliferative disease. Studies show that NTB-A is its own ligand and homophilic interaction of NTB-A enhances NK cell cytotoxicity and influences NK cell proliferation and IFN- secretion. It is also suggested that NTB-A is an interlymphocyte signaling molecule, which serves to orchestrate the activities of immune cells. Dysregulation of SLAMF6 signaling is associated with autoimmune conditions such as systemic lupus erythematosus (SLE), where it can contribute to abnormal immune cell activation. (Ref.: Flaig, R.M., et al. (2004). J Immunol. 172(11):6524-7; Stark, S., et al. (2005). J Immunol Methods. 296(1-2):149-58; Messmer, B., et al. (2006). J Immunol. 176(8):4646-50).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ200
      Applications
      ApplicationAnti-SLAMF6/NTB-A, clone NT-7 , Cat. No. MABF3081, is a mouse monoclonal antibody that detects NTB-A/CD352 and is tested for use in Flow Cytometry and ELISA.
      Key Applications
      • Flow Cytometry
      • ELISA
      Application NotesTested Applications

      ELISA: A representative lot detected NTB-A/CD352 in ELISA application (Stark, S., et al. (2005). J Immunol Methods. 296(1-2):149-58).

      Flow Cytometry Analysis: A representative lot detected NTB-A/CD352 in Flow Cytometry application (Flaig, R.M., et al. (2004). J Immunol. 172(11):6524-7; Messmer, B., et al. (2006). J Immunol. 176(8):4646-50).

      Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user.
      Biological Information
      ImmunogenRecombinant fragment from extracellular domain of human SLAMF6/NTB-A.
      EpitopeExtracellular domain
      CloneNT-7
      Concentration1.0 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
      HostMouse
      SpecificityClone NT-7 is a mouse monoclonal antibody that specifically detects SLAMF6/NTB-A. It targets an epitope within the extracellular domain.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SLAMF6
      Purification MethodProtein G purified
      UniProt Number
      Molecular WeightTarget molecular weight; 37.34 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in Human peripheral blood mononuclear cells (PBMC).

      Flow Cytometry Analysis: 1.0ug of this antibody detected SLAMF6/NTB-A in one million Human peripheral blood mononuclear cells (PBMC).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsRecommended storage: +2°C to +8°C.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABF3081-25UG 04065272290227

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