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ABE1312 Anti-SF3b155 (SAP 155) Antibody

Anti-SF3b155 (SAP 155) is an antibody against SF3b155 (SAP 155) for use in WB, ICC.

Anti-SF3b155 (SAP 155) Antibody: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Nuclear Receptors Gene Symbol: SF3B1, SAP155 UniProt Number: O75533
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ABE1312
100 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE1312
      DescriptionAnti-SF3b155 (SAP 155) Antibody
      Alternate Names
      • Splicing factor 3B subunit 1
      • Pre-mRNA-splicing factor SF3b 155 kDa subunit
      • SF3b155
      • Spliceosome-associated protein 155
      • SAP 155
      Background InformationSplicing factor 3B subunit 1, also known as Pre-mRNA-splicing factor SF3b 155 kDa subunit (SF3b155), Spliceosome-associated protein 155 (SAP 155), and encoded by the gene name SF3B1 or SAP155, is a member of the SF3B1 family . SF3B155 (SAP 155) functions a s a subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. SF3B155 (SAP 155) has been implied to be involved in the assembly of the 'E' complex, and also may anchor U2 snRNP to the pre-mRNA. Additionally, SF3B155 (SAP 155) belongs to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. SF3B155 (SAP 155) has been identified in the spliceosome C complex, as a component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Phosphorylation of SF3B155 (SAP 155) occurs concomitantly with the splicing catalytic steps. The phosphorylation on Thr-244, Thr-248 and Thr-313 by cyclin-dependent kinases promotes interaction with PPP1R8 during mitosis. SF3B155 (SAP 155) is located in the nucleus speckle and during mitosis, it is transiently dispersed from the nuclear speckles to the cytoplasm.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-SF3b155 (SAP 155) is an antibody against SF3b155 (SAP 155) for use in WB, ICC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A 1:1,000 dilution from a representative lot detected SF3b155 (SAP 155) in HeLa, A431, and NIH/3T3 cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human SF3b155 (SAP 155) near the N-terminus.
      EpitopeNear N-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SF3B1
      • SAP155
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~160 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

      Western Blotting Analysis: A 1:10,000 dilution of this antibody detected SF3b155 (SAP 155) in 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABE1312 04055977113600

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      Kategorien

      Life Science Research > Antibodies and Assays > Primary Antibodies