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ABE1033 Anti-RBM4 Antibody

Anti-RBM4 Antibody is an antibody against RBM4 Antibody for use in Western Blotting, Immunocytochemistry.

Anti-RBM4 Antibody: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Nuclear Receptors Gene Symbol: RBM4, RBM4A UniProt Number: Q9BWF3
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ABE1033
200 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE1033
      DescriptionAnti-RBM4 Antibody
      Alternate Names
      • RNA-binding protein 4
      • Lark homolog
      • hLark
      • RNA-binding motif protein 4
      • RNA-binding motif protein 4a
      • RBM4
      Background InformationRBM4 is a widely expressed RNA-binding factor involved in many cellular process, including alternative splicing of pre-mRNA and translation regulation by modulating alternative 5'-splice site and exon selection on target hnRNA. RBM4 plays roles in development, particularly muscle cell development, clock metabolism and cellular stress. In muscle, RBM4 acts as a muscle cell differentiation-promoting factor and activates exon skipping of the PTB pre-mRNA during muscle cell differentiation, and it antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. RBM4 also mediates various mRNA functions important for myocytes, and RBM4 associates with important miRNAs that are important for muscle cell differentiation. RBM4 is also involved in regulation of the biological clock because it is required for the translational activation of PER1 mRNA in response to circadian clock. In cellular stress, RBM4 recruits EIF4A1 to stimulate IRES-dependent translation initiation in response to cellular stress, and RBM4 associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-RBM4 Antibody is an antibody against RBM4 Antibody for use in Western Blotting, Immunocytochemistry.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: 2.0 µg/mL from a representative lot detected RBM4 in HeLa and A431 cells.
      Biological Information
      ImmunogenHis-tagged recombinant protein corresponding to human RBM4.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Monkey based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • RBM4
      • RBM4A
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~42 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HepG2 cell lysate.

      Western Blotting Analysis: A 1:250 dilution of this antibody detected RBM4 in 10 µg of HepG2 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABE1033 04055977127300