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MAB5326C3 Anti-Nestin Antibody, clone 10C2, Cy3 conjugate

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MAB5326C3
100 µL  
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      Übersicht

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HICCMCy3Monoclonal Antibody
      Description
      Catalogue NumberMAB5326C3
      DescriptionAnti-Nestin Antibody, clone 10C2, Cy3 conjugate
      Alternate Names
      • Nestin10c2
      • NES
      • Nbla00170
      • FLJ21841
      Background InformationNestin, a large intermediate filament protein (class Type VI) expressed during development and in myotendinous and neuromuscular junctions. Nestin expression is restricted, typically disappearing by E18. Nestin is thought to be a reasonable neuronal marker; however, recent studies have found nestin expression in other cell types such as endothelial cells {Folia Biologica, 44(5):155, 1998}. Nestin identifies the most primitive neuroepithelium but also identifies many other embryonic tissues, so it is not specific for CNS. Nestin expression is seen in almost all GBMs (Glioblastoma mulitformes) and many melanomas (both primary and metastatic) but not in any metastatic carcinoma.
      References
      Product Information
      FormatCy3
      Control
      • RNcell CX neural stem cells (SCC007).
      PresentationPurified mouse monoclonal IgG1 conjugated to Cy3 in PBS with 0.1% sodium azide and 15mg/ml BSA.
      Quality LevelMQ100
      Applications
      ApplicationDetect Nestin using this Anti-Nestin Antibody, clone 10C2, Cy3 conjugate validated for use in ICC.
      Key Applications
      • Immunocytochemistry
      Biological Information
      ImmunogenFusion protein corresponding to human Nestin.
      Clone10C2
      HostMouse
      SpecificityThis antibody recognizes human Nestin. Antibody is not reactive with rat or mouse Nestin protein.
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NES
      • Nbla00170
      • FLJ21841
      • Nestin.
      Purification MethodProtein A Purfied
      UniProt Number
      Molecular WeightThe uncojugated parent antibody (Catalog No. MAB5326) has an observed MW at 200-220 kDA.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunocytochemistry in human RNcell CX neural stem cells (SCC007). Immunocytochemsitry Analysis: A 1:100 dilution of this antibody detected Nestin in human RNcell CX neural stem cells (SCC007).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8ºC protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MAB5326C3 04053252648519

      Documentation

      Anti-Nestin Antibody, clone 10C2, Cy3 conjugate SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Anti-Nestin Antibody, clone 10C2, Cy3 conjugate Analysenzertifikate

      TitelChargennummer
      Anti-Nestin, clone 10C2, Cy3 -2702164 2702164
      Anti-Nestin, clone 10C2, Cy3 -2807770 2807770
      Anti-Nestin, clone 10C2, Cy3 Conjugate 2923064
      Anti-Nestin, clone 10C2, Cy3 conjugate - 2190463 2190463
      Anti-Nestin, clone 10C2, Cy3 conjugate - 2202475 2202475
      Anti-Nestin, clone 10C2, Cy3 conjugate - 2300010 2300010
      Anti-Nestin, clone 10C2, Cy3 conjugate - 3166078 3166078
      Anti-Nestin, clone 10C2, Cy3 conjugate - 3822810 3822810
      Anti-Nestin, clone 10C2, Cy3 conjugate - 4133760 4133760
      Anti-Nestin, clone 10C2, Cy3 conjugate - Q2025117 Q2025117

      Literatur

      ÜbersichtPub Med ID
      Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model.
      Endersby, R; Zhu, X; Hay, N; Ellison, DW; Baker, SJ
      Cancer research  71  4106-16  2010

      Abstract anzeigen
      21507933 21507933
      GFAPdelta in radial glia and subventricular zone progenitors in the developing human cortex.
      Middeldorp, Jinte, et al.
      Development, 137: 313-21 (2010)  2009

      Abstract anzeigen
      20040497 20040497
      The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells.
      Aguado, Tania, et al.
      J. Neurosci., 26: 1551-61 (2006)  2005

      Abstract anzeigen
      16452678 16452678
      Differentiation of human embryonic stem cells to dopaminergic neurons in serum-free suspension culture.
      Thomas C Schulz, Scott A Noggle, Gail M Palmarini, Deb A Weiler, Ian G Lyons, Kate A Pensa, Adrian C B Meedeniya, Bruce P Davidson, Nevin A Lambert, Brian G Condie
      Stem cells (Dayton, Ohio)  22  1218-38  2004

      Abstract anzeigen
      15579641 15579641
      Coexpression of nestin in neural and glial cells in the developing human CNS defined by a human-specific anti-nestin antibody.
      Messam, C A, et al.
      Exp. Neurol., 161: 585-96 (2000)  1999

      10686078 10686078

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      Kategorien

      Life Science Research > Antibodies and Assays > Primary Antibodies