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MABF216 Anti-Microsialin/CD68 Antibody, clone 9

Anti-Microsialin/CD68 Antibody, clone 9 is an antibody against Microsialin/CD68 for use in flow cytometry.

Anti-Microsialin/CD68 Antibody, clone 9: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: Cd68 UniProt Number: P31996
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MABF216
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFCRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF216
      DescriptionAnti-Microsialin/CD68 Antibody, clone 9
      Alternate Names
      • Macrosialin
      • CD68
      Background InformationMicrosialin/CD68, also known as Macrosialin, Gp110, CD_antigen 68, or CD68, and encoded by the gene CD68, is a membrane protein expressed in macrophages (and other cells) that appears to play a role in the phagocytic activities of tissue macrophages both in intracellular lysosomal metabolism but also in extracellular cell to cell interactions and cell pathogen interactions. Microsialin binds to tissue and organ-specific lectins or selectins mediating homing of macrophage subsets to particular sites. Also, rapid recirculation of Microsialin from the endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selection-bearing substrates or other cells. Microsialin is expressed in blood monocytes and tissue macrophages primarily but is also found expressed in lymphocytes, fibroblasts and endothelial cells so it is not an exclusive marker for macrophages. Also Microsialin is expressed on many tumor cells which seem to allow the tumor cells to attach to selectins on the vascular endothelium facilitating their dissemination to secondary sites.
      References
      Product Information
      FormatPurified
      PresentationPurified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Microsialin/CD68 Antibody, clone 9 is an antibody against Microsialin/CD68 for use in flow cytometry.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenRecombinant protein corresponding to mouse Microsialin/CD68.
      Clone9
      Concentration1 mg/mL
      HostRat
      IsotypeIgG2aκ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Cd68
      Purification MethodProtein G Purified
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in RAW264.7 cells.

      Flow Cytometry Analysis: 2 µg of this antibody detected Microsialin/CD68 in 1X10E6 cells.

      This antibody was produced in collaboration with the Scripps Research Institute. For Scripps Research Institute Validation (Click Here)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABF216 04053252977688