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ABS1624 Anti-Lunapark Antibody

Detect Lunapark using this Anti-Lunapark Antibody validated for use in Western Blotting.

Anti-Lunapark Antibody : SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Signaling Research Sub-Category: Developmental Signaling Gene Symbol: LNP, KIAA1715 UniProt Number: Q9C0E8
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ABS1624
100 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MkWBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberABS1624
      DescriptionAnti-Lunapark Antibody
      Alternate Names
      • Protein lunapark
      • Ulnaless
      Background InformationProtein lunapark (UniProt Q9C0E8; also known as Ulnaless) is encoded by the LNP (also known as KIAA1715) gene (Gene ID 80856) in human. The endoplasmic reticulum (ER) consists of a polygonal network of sheets and tubules interconnected by three-way junctions that undergoes continual remodeling through two competing processes. The branching and fusion of tubules lead to the formation of new three-way junctions and polygons, while junction sliding and ring closure lead to polygon loss. Both yeast Lnp1 and mammalian lunapark (mLnp1) are reported to play an important role in the maintenance of ER morphology through junctions stabilization. Study conducted in COS-7 cells demonstrated that junctions with lunapark are less mobile than junctions lacking lunapark. New junctions acquired lunapark tend to remain stable within the ER network, whereas the nascent junctions that fail to acquire lunapark preferentially undergo ring closure.
      References
      Product Information
      FormatSerum
      PresentationRabbit polyclonal serum with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Lunapark using this Anti-Lunapark Antibody validated for use in Western Blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: The purified antibody was used to detect Lunapark expression in COS-7 cells and confirm siRNA-medidated Lunapark downregulation (Chen, S., et al. (2015). Proc. Natl. Acad. Sci. U. S. A. 112(2):418-423).
      Biological Information
      ImmunogenGST-tagged full-length recombinant human Lunapark.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityExprected to react with all four spliced isoforms of human lunapark reported by UniProt (Q9C0E8).
      Species Reactivity
      • Human
      • Monkey
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • LNP
      • KIAA1715
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~47 kDa observed. 47.74 kDa (isoform 1), 47.09 kDa (isoform 2), 33.01 kDa (isoform 3), and 50.85 kDa (isoform 4) calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

      Western Blotting Analysis: A 1:5,000 dilution of this antibody detected Lunapark in 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABS1624 04055977315752