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MABF3091-25UG Anti-LMP1 Antibody, clone 1G6

This rat monoclonal Anti-LMP1, clone 1G6, Cat. No. MABF3091 is tested for use in Immunocytochemistry, Western Blotting, and Immunohistochemistry, for the detection of Latent membrane protein 1 (LMP1).

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25 μg  
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      Übersicht

      Replacement Information
      Description
      Catalogue NumberMABF3091-25UG
      DescriptionAnti-LMP1 Antibody, clone 1G6
      Alternate Names
      • LMP-1
      • Protein p25
      • Protein p63
      Background InformationLatent membrane protein 1 (LMP1) (UniProt: P03230) is encoded by the LMP1 (also known as BNLF1) gene (Gene ID: 3783750) in Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4). Latent membrane protein 1 (LMP1) is a viral oncoprotein encoded by the Epstein-Barr virus (EBV) and is known for its critical role in EBV-associated oncogenesis. LMP1 functions as a constitutively active mimic of the tumor necrosis factor receptor (TNFR) and can activate various signaling pathways, including NF- B, JNK, and PI3K/Akt. Through its ability to modulate these pathways, LMP1 can promote cell proliferation, inhibit apoptosis, and induce the expression of various cytokines and growth factors. Additionally, LMP1 contributes to the immortalization of infected B cells and is implicated in the pathogenesis of EBV-associated malignancies, including Hodgkin's lymphoma and nasopharyngeal carcinoma.
      References
      Product Information
      FormatPurified
      PresentationPurified rat monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ200
      Applications
      ApplicationThis rat monoclonal Anti-LMP1, clone 1G6, Cat. No. MABF3091 is tested for use in Immunocytochemistry, Western Blotting, and Immunohistochemistry, for the detection of Latent membrane protein 1 (LMP1).
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry
      • Western Blotting
      Application NotesTested Applications

      Immunohistochemistry Analysis: A representative lot detected LMP1 in Immunohistochemistry applications (Nicholls, J., et al. (2004). J Virol Methods. 116(1):79-88; Shair, K.H.Y., et al. (2007). PLoS Pathog. 3(11):e166).

      Immunocytochemistry Analysis: A representative lot detected LMP1 in Immunocytochemistry applications (Nicholls, J., et al. (2004). J Virol Methods. 116(1):79-88).

      Western Blotting Analysis: A representative lot detected LMP1 in Western Blotting applications (Nicholls, J., et al. (2004). J Virol Methods. 116(1):79-88; Thornburg, N.J., et al. (2006). Oncogene. 25(2):288-97; Hannigan, A., et al. (2010). Mol Cancer. 9:9:184; Rancan, C., et al. (2015). PLoS Pathog. 11(6):e1004906).

      Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user.
      Biological Information
      ImmunogenWild type LMP1-TrpE-fusion protein from Epstein-Barr virus.
      EpitopeC-terminal cytoplasmic domain
      Clone1G6
      Concentration1.0 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
      HostRat
      SpecificityClone 1G6 is a rat monoclonal antibody that detects LMP1. It targets an epitope within the C-terminal cytoplasmic domain of the protein.
      IsotypeIgG2a
      Species Reactivity
      • Virus
      Species Reactivity NoteVirus.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • LMP1
      Purification MethodProtein G purified
      UniProt Number
      Molecular WeightTarget molecular weight 41.98 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunocytochemistry in B95-8 cells.

      Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected LMP1 in B95-8 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsRecommended storage: +2°C to +8°C.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABF3091-25UG 04065271270091