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MABN873 Anti-Kallikrein 6/KLK6 Antibody, clone E24

Anti-Kallikrein 6/KLK6 Antibody, clone E24 is an antibody against Kallikrein 6/KLK6 for use in Immunohistochemistry (Paraffin), ELISA, Inhibits Activity/Function, Immunoaffinity Purification.

Anti-Kallikrein 6/KLK6 Antibody, clone E24 : SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: KLK6, PRSS18, PRSS9 UniProt Number: Q92876
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MABN873
100 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MIH(P), ELISA, INHIB, IAPMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN873
      DescriptionAnti-Kallikrein 6/KLK6 Antibody, clone E24
      Alternate Names
      • Kallikrein-6
      • hK6
      • Neurosin
      • Protease M
      • Serine protease 18
      • Serine protease 9
      • SP59
      • Zyme
      Background InformationKallikrein-6 (UniProt Q92876; also known as hK6, Neurosin, Protease M, Serine protease 18, Serine protease 9, SP59, Zyme) is encoded by the KLK6 (also known as PRSS18, PRSS9) gene (Gene ID 5653) in human. Kallikrein-6 belongs to the kallikrein subfamily of serine proteases, members of which are involved in diverse physiological functions and many are used clinically as biomarkers for cancers. Originally identified due to its aberrant expression in mammary and ovarian cancers, kallikrein-6 is expressed in a wide range of tissues, including breast, kidney, and the central nervous system. Kallikrein-6 is known to cleave components of the extracellular matrix (ECM) and is reported to be involved in multiple cellular processes, including inflammation, receptor activation, and apoptosis. In addition, deregulated KLK6 expression occurs in neurodegenerative and skin disorders, and is a common event in many types of human cancers. Consequently, KLK6 represents a promising biomarker of early diagnosis and/or unfavorable prognosis in these human malignancies. Kallikrein-6 is initially produced as a preproprotein with a signal (aa 1-16) and a propeptide (aa 17-21), cleavage of which releases the mature protein (aa 22-244).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in 0.1 M Sodium bicarbonate buffer, pH 8.2 with 0.02% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Kallikrein 6/KLK6 Antibody, clone E24 is an antibody against Kallikrein 6/KLK6 for use in Immunohistochemistry (Paraffin), ELISA, Inhibits Activity/Function, Immunoaffinity Purification.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • ELISA
      • Inhibits Activity/Function
      • Immunoaffinity Purification
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Kallikrein 6/KLK6 in mouse cerebral cortex tissue.
      ELISA Analysis: Representative lots were conjugated with biotin and used as the detection antibody for analyzing kallikrein-6 levels in ovarian cytosolic extracts as well as ascites fluids from ovarian cancer patients (Shan, S.J., et al. (2007). Br. J. Cancer. 96(2):362-372; Luo, L.Y., et al. (2006). Tumor Biol. 27:227-234).
      Activity/Function Inhibition Analysis: Representative lots inhibited the catalytic activity of purified human kallikrein-6 (hK6) from ascites fluid as well as recombinant hK6 in cell-free enzymatic assays (Sotiropoulou, G., et al. (2012). Chem. Cent. J. 6(1):148; Luo, L.Y., et al. (2006). Tumor Biol. 27:227-234; Ghosh, M.C., et al. Tumor Biol. (2004). 25(4):193-199).
      Immunoaffinity Purification: Representative lots were conjugated to resins and employed for affinity purification of kallikrein-6 from human ascites fluid, cerebrospinal fluid (CSF), and breast milk (Luo, L.Y., et al. (2006). Tumor Biol. 27:227-234; Hutchinson, S., et al. (2003). Clin. Chem. 49(5):746-751).
      Biological Information
      ImmunogenRecombinant full-length human Kallikrein 6.
      CloneE24
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone E24 reacts with kallikrein-6, but not other kallikrein family members. Reactivity against kallikrein-6 spliced isoforms 2&3 reported by UniProt (Q92876) has not been determined.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KLK6
      • PRSS18
      • PRSS9
      UniProt Number
      Molecular Weight26.85 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human cerebral cortex tissue.

      Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Kallikrein 6/KLK6 in human cerebral cortex tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABN873 04055977334357