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ABC74 Anti-IGPR-1 Antibody

Anti-IGPR-1 antibody is an antibody against IGPR-1 for use in western blotting, ICC & IHC.

Anti-IGPR-1 Antibody: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: TMIGD2, IGPR1 UniProt Number: Q96BF3
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ABC74
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, HWB, ICC, IHCRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC74
      DescriptionAnti-IGPR-1 Antibody
      Alternate Names
      • Transmembrane and immunoglobulin domain-containing protein 2
      • Immunoglobulin and proline-rich receptor 1
      • IGPR-1
      Background InformationIGPR-1 or Immunoglobulin and proline-rich receptor 1, also called Transmembrane and immunoglobulin domain-containing protein 2 and encoded by the human gene TMIGD2/IGPR1 is a widely expressed epithelial and endothelial membrane protein that plays a role in cell-cell interactions, cell migration and angiogenesis. IGPR-1 regulates cellular morphology, homophilic cell aggregation, and cell-cell interaction. IGPR-1 activity also modulates actin stress fiber formation and focal adhesion and reduces cell migration. Silencing of expression of IGPR-1 by small interfering RNA (siRNA) and by ectopic overexpression in endothelial cells showed that IGPR-1 regulates capillary tube formation in vitro, and in B16F melanoma cells engineered to express IGPR-1 displayed extensive angiogenesis in the mouse Matrigel angiogenesis model. Moreover, IGPR-1, through its proline-rich cytoplasmic domain, associates with multiple Src homology 3 (SH3)-containing signaling proteins, including SH3 protein interacting with Nck (SPIN90/WISH), bullous pemphigoid antigen-1, and calcium channel β2.
      References
      Product Information
      FormatPurified
      PresentationPurified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-IGPR-1 antibody is an antibody against IGPR-1 for use in western blotting, ICC & IHC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunohistochemistry
      Application NotesWestern Blotting Analysis: 2 µg/mL from a representative lot detected IGPR-1 in 10 µg of HepG2 cell lysate, human placenta tissue lysate, HUVEC cell lysate, and L9 cell lysate.

      Western Blotting Analysis: A representative lot from an independent laboratory detected IGPR-1 in IGPR-1 transfected PAE cell lysates (Rahimi, N., et al. (2012). Mol Cell Biol. 23(9):1646-1556.).

      Immunocytochemistry Analysis: A representative lot from an independent laboratory detected IGPR-1 in IGPR-1 transfected PAE cells (Rahimi, N., et al. (2012). Mol Cell Biol. 23(9):1646-1556.).

      Immunohistochemistry Analysis: A representative lot from an independent laboratory detected IGPR-1 in human colon cancer tissues (Rahimi, N., et al. (2012). Mol Cell Biol. 23(9):1646-1556.).
      Biological Information
      ImmunogenLinear peptide corresponding to the cytoplasmic domain of the human mature form of IGPR-1.
      EpitopeCytoplasmic domain
      Concentration1 mg/mL
      HostRabbit
      Species Reactivity
      • Rat
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TMIGD2
      • IGPR1
      Purification MethodProtein A Purfied
      UniProt Number
      Molecular Weight~58 kDa observed. Uniprot describes two isoforms at 31 kDa and 30 kDa. The pre-mature and mature form of this protein may be observed at 32 kDa and 58 kDa (Rahimi, N., et al. (2012). Mol Cell Biol. 23(9):1646-1556.). Uncharacterized band(s) may be observed in some cell lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in PC-12 cell lysate.

      Western Blotting Analysis: 2 µg/mL of this antibody detected IGPR-1 in 10 µg of PC-12 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABC74 04053252970047