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ABC110 Anti-ELMO1 Antibody

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ABC110
50 µg  
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      Übersicht

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC110
      DescriptionAnti-ELMO1 Antibody
      Alternate Names
      • Engulfment and cell motility protein 1
      • Protein ced-12 homolog
      Background InformationEngulfment and cell motility protein 1 (ELMO1) is a cytoplasmic protein involved in the clearance of apoptotic cells by phagocytosis. ELMO1 is activated downstream of the phosphatidylserine receptor BAI1. ELMO1 binds to DOCK180 and facilitates its transport to the plasma membrane where DOCK180 activates the GTPase RAC1, possibly via Arf6. RAC1, like other small GTPases, mediate cytoskeleton remodeling and cell motility which is necessary for the internalization of target cells.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Jurkat cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect ELMO1 using this Anti-ELMO1 Antibody validated for use in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human ELMO1 at the ELMO domain.
      EpitopeELMO domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes ELMO1 at the ELMO domain.
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with Human. Predicted to react with Mouse, Bovine, and Rhesus Macaque based on 100% sequence homology. No homology to Rat was found.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ELMO1
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~78 kDa observed. This antibody exhibits strong affinity, high dilutions are recommended. The calculated molecular weight is 84 kDa, however ELMO1 has been shown as a ~78 kDa band in western blots (Gumienny, T.L., et al. (2001). Cell. 107:27–41.)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in Jurkat cell lysate.

      Western Blot Analysis: 0.1 µg/mL of this antibody detected ELMO1 on 10 µg of Jurkat cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABC110 04053252694684

      Documentation

      Anti-ELMO1 Antibody SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Anti-ELMO1 Antibody Analysenzertifikate

      TitelChargennummer
      Anti-ELMO1 - 2448423 2448423
      Anti-ELMO1 - 3974649 3974649
      Anti-ELMO1 - Q2037408 Q2037408
      Anti-ELMO1 -2608182 2608182

      Literatur

      ÜbersichtPub Med ID
      CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.
      Gumienny, T L, et al.
      Cell, 107: 27-41 (2001)  2001

      Abstract anzeigen
      11595183 11595183

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      Kategorien

      Life Science Research > Antibodies and Assays > Primary Antibodies