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MABC196 Anti-Chitinase-3-like protein 1 (YKL-40) Antibody, clone mAY

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MABC196
100 µg  
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      Übersicht

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHC, ACTMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC196
      DescriptionAnti-Chitinase-3-like protein 1 (YKL-40) Antibody, clone mAY
      Alternate Names
      • Chitinase-3-like protein 1
      • 39 kDa synovial protein
      • Cartilage glycoprotein 39
      • CGP-39
      • GP-39
      • hCGP-39
      • YKL-40
      Background InformationYKL-40 (Chitinase-3-like protein 1; human cartilage glycoprotein 39) is a secreted glycoprotein belonging to the glycosyl hydrolase 18 (GH18) family. It is found primarily in chondrocytes, activated macrophages, and hepatocytes. The precise biological function of YKL-40 is still unknown; however, recent studies suggest that YKL-40 may play a role in cell differentiation and inflammation. YKL-40 is elevated in the sera of patients with inflammatory diseases or cancer, and it is currently being investigated as a potential biomarker for these conditions.
      Product Information
      FormatPurified
      Control
      • MG-63 conditioned media
      PresentationPurified mouse monoclonal IgG1κ in buffer containing PBS without preservatives.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Chitinase-3-like protein 1 (YKL-40) Antibody, clone mAY is validated for use in Western Blotting, IHC, Activity Assay for the detection of Chitinase-3-like protein 1 (YKL-40).
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Activity Assay
      Application NotesImmunocytochemistry Analysis: A representative lot from an independent laboratory detected Chitinase-3-like protein 1 (YKL-40) in U87 cells (This protein blocks tumor angiogenesis tube formation and progression (Faibish, M., et al. (2011). Mol Cancer Ther. 10(5):742-751.)).

      Activity Assay Analysis: A representative lot from an independent laboratory neutralized Chitinase-3-like protein 1 in a neutralization assay (Faibish, M., et al. (2011). Mol Cancer Ther. 10(5):742-751.).
      Biological Information
      ImmunogenRecombinant protein corresponding to human Chitinase-3-like protein 1 (YKL-40).
      ClonemAY
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CHI3L1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~42 kDa observed
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in MG-63 conditioned media.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected Chitinase-3-like protein 1 (YKL-40) in 10 µg of MG-63 conditioned media (This protein blocks tumor angiogenesis tube formation and progression (Faibish, M., et al. (2011). Mol Cancer Ther. 10(5):742-751.)).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Bestellnummer GTIN
      MABC196 04053252648342